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iRGD decorated liposomes: A novel actively penetrating topical ocular drug delivery strategy

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Abstract

Ocular drug delivery remains a significant challenge that is limited by poor corneal retention and permeation, resulting in low ocular bioavailability (< 5%). Worse still, the most convenient and safe route of ocular drug administration, topical administration results in a drug bioavailability of less than 1%. iRGD modified drug delivery strategies have been developed for cancer therapy, however active targeting iRGD platforms for ocular drug delivery have yet to be explored. Herein, an iRGD modified liposomes was developed for ocular drug delivery via topical administration. The results indicated that iRGD modified liposomes could prolong the corneal retention time and enhance corneal permeability in an iRGD receptor mediated manner. These findings provided a novel strategy for topical ocular drug delivery for the treatment of posterior ocular diseases.

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Acknowledgements

This work was financially supported by the National Key S&T Special Projects (No. 2018ZX09201018-024) and Sichuan Province Science and Technology Plan (2019YFH0115).

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Author notes

  1. Hai Huang and Xiaorong Yang contributed equally to this work.

Authors and Affiliations

  1. Outpatient Department, Department of Critical Care Medicine, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, China

    Hai Huang, Xiaorong Yang, Huili Li, Hansi Lu, Yongmei Liu, Jun Zeng, Chaohui Jin, Xingchen Peng, Jiyan Liu & Xiangrong Song

  2. School of Nanotechnology Engineering, University of Waterloo, Waterloo, ON, N2L 3G1, Canada

    James Oswald

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  1. Hai Huang
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  2. Xiaorong Yang
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  3. Huili Li
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  4. Hansi Lu
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  6. Yongmei Liu
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  11. Xiangrong Song
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Correspondence to Xiangrong Song.

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Huang, H., Yang, X., Li, H. et al. iRGD decorated liposomes: A novel actively penetrating topical ocular drug delivery strategy. Nano Res. 13, 3105–3109 (2020). https://doi.org/10.1007/s12274-020-2980-9

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  • DOI: https://doi.org/10.1007/s12274-020-2980-9

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