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Multifunctional lymph-targeted platform based on Mn@mSiO2 nanocomposites: Combining PFOB for dual-mode imaging and DOX for cancer diagnose and treatment

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Abstract

A universal platform with Mn doping and hyaluronic acid (HA) modification, based on mesoporous silica (mSiO2), was designed and used as a basic multifunctional material with magnetic resonance (MR) imaging. Furthermore, we added flexible functions through the addition of functional molecules. Specially, two typical compounds, hydrophobic perfluorooctyl bromide (PFOB) and hydrophilic doxorubicin (DOX), were loaded into the channels to obtain PFOB@Mn@mSiO2@HA (PMMH) or DOX@Mn@mSiO2@HA (DMMH) nanoparticles for dual-mode imaging or imaging and therapy, respectively. The PMMH and DMMH nanoparticles were highly targeted to the lymph system in vitro and in vivo. MR and ultrasound imaging of PMMH nanoparticles were performed in the lymph system, while MR imaging and chemotherapy of DMMH nanoparticles was used to detect cancer. These results showed that both PMMH and DMMH nanoparticles can be designed with high lymph targeting efficiency. PMMH nanoparticles are a dual-mode contrast agent for both ultrasound and MR imaging for the lymph system and DMMH nanoparticles are powerful agents for the combined diagnosis and therapy of cancer in vivo.

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Authors and Affiliations

  1. Country School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China

    Tian Liu, Yanjie Yao, Zhenjing Liu, Dongchen Zhu & Dannong He

  2. National Engineering Research Center for Nanotechnology, 28 East Jiang Chuan Road, Shanghai, 200241, China

    Tian Liu, Yanjie Yao, Juan Zhou & Jun Zhu

  3. Department of Radiology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, 1630 Dong Fang Rd, Shanghai, 200127, China

    Guangyu Wu, Jiejun Cheng, Qing Lu & Jianrong Xu

Authors
  1. Tian Liu
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  2. Guangyu Wu
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  3. Jiejun Cheng
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  4. Qing Lu
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  5. Yanjie Yao
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  6. Zhenjing Liu
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  7. Dongchen Zhu
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  8. Juan Zhou
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  9. Jianrong Xu
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  10. Jun Zhu
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  11. Dannong He
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Correspondence to Jianrong Xu, Jun Zhu or Dannong He.

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These authors contributed equally to this work.

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Liu, T., Wu, G., Cheng, J. et al. Multifunctional lymph-targeted platform based on Mn@mSiO2 nanocomposites: Combining PFOB for dual-mode imaging and DOX for cancer diagnose and treatment. Nano Res. 9, 473–489 (2016). https://doi.org/10.1007/s12274-015-0929-1

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