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Non-glycosidic iridoids from the roots of Patrinia scabra and their nitric oxide production inhibitory effects

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Abstract

Phytochemical investigation on the 70% aqueous EtOH extract from the roots of Patrinia scabra led to the isolation and characterization of five new non-glycosidic iridoids, patriscabrins F–J (1–5), along with a known iridoid 11-ethoxyviburtinal (6). The structures of the new compounds 1–5 were determined by interpretation of spectroscopic data, particularly by 1D- and 2D-NMR and ECD studies. Thereafter, the isolates 1–6 were evaluated for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells. Of these, patriscabrin F (1) exhibited the most potent inhibitory effect with observed IC50 value of 14.1 μM. In addition, patriscabrin G (2) and 11-ethoxyviburtinal (6) showed IC50 values 24.6 and 35.5 μM, respectively.

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Acknowledgement

This research was supported by a Grant from the Bio-Synergy Research Project (NRF-2015M3A9C4070483) of the Ministry of Science, ICT and Future Planning through the National Research Foundation of Korea (NRF), and by Basic Science Research Program through the NRF funded by the Ministry of Education (NRF-2016R1D1A1B03930222).

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Authors and Affiliations

  1. Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, 02447, Republic of Korea

    Da Hye Lee, Ji-Sun Shin, Jin Su Lee, Shin-Young Kang, Hee-Soo Han, Kyung-Tae Lee & Dae Sik Jang

  2. Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea

    Seung Mok Ryu & Dongho Lee

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  1. Da Hye Lee
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Correspondence to Dongho Lee or Dae Sik Jang.

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Lee, D.H., Shin, JS., Lee, J.S. et al. Non-glycosidic iridoids from the roots of Patrinia scabra and their nitric oxide production inhibitory effects. Arch. Pharm. Res. 42, 766–772 (2019). https://doi.org/10.1007/s12272-019-01117-0

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