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Chemical constituents of the roots of Codonopsis lanceolata

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Abstract

A new phenylpropanoid (1), a new alkaloid (11), and a new natural polyacetylene (17), together with nine phenolic compounds (2–10), five alkaloids (12–16), three polyacetylenes (18–20), three triterpenoidal saponins (21–23), one phenylethanoid glycoside (24), and three hexyl glycosides (25–27) with previous known structures, were isolated from the roots of Codonopsis lanceolata. All of the isolates 1–27 were evaluated for their inhibitory effects on LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages and cell viability in A2780 human ovarian cancer cells. Among the isolates, lancemasides A and B have a significant inhibitory effect on the production of NO in RAW264.7 cells (IC50 values < 50 μM). In A2780 cells, lancemaside A exhibited the most potent inhibitory effect on cell viability. This is the first report on the pharmacological activities of lancemaside B (22).

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Acknowledgements

This research was supported by Basic Science Research Program through the NRF funded by the Ministry of Education (NRF-2016R1D1A1B03930222), and by a grant from the High Value-added Food Technology Development Program, Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (113036-04-1-HD020).

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Authors and Affiliations

  1. Department of Life & Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, 02447, Republic of Korea

    Young Eun Du, Jin Su Lee, In Ho Jung, Jong Hoon Ryu, Jung-Hye Choi & Dae Sik Jang

  2. College of Pharmacy, Kyung Hee University, Seoul, 02447, Republic of Korea

    Young Eun Du, Jin Su Lee, Hye Mi Kim, Ji-Hye Ahn, Jong Hoon Ryu, Jung-Hye Choi & Dae Sik Jang

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  1. Young Eun Du
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Du, Y.E., Lee, J.S., Kim, H.M. et al. Chemical constituents of the roots of Codonopsis lanceolata. Arch. Pharm. Res. 41, 1082–1091 (2018). https://doi.org/10.1007/s12272-018-1080-9

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