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Therapeutic applications of electrospun nanofibers for drug delivery systems

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Abstract

Electrospun nanofiber drug delivery systems have been studied using various techniques. Herein, we describe the fabrication of a drug-incorporating nanofiber. Drugs, such as proteins, peptide, antibodies, and small molecule drugs, can be loaded within or on the surface of nanofibers according to their properties. Hydrophobic drugs are directly dissolved with a polymer in an organic solvent before electrospinning. However, it is preferred to surface-immobilize bioactive molecules on nanofibers by physical absorption or chemical conjugation. Especially, chemically surface-immobilized proteins on a nanofiber mesh stimulate cell differentiation and proliferation. Using a dual electrospinning nozzle to create nanofiber sheet layers, which are stacked on top of one another, the initial burst release is reduced compared with solid nanofibers because of the layers. Furthermore, hybridization of electrospun nanofibers with nanoparticles, microspheres, and hydrogels is indirect drug loading method into the nanofibers. It is also possible to produce multi-drug delivery systems with timed programmed release.

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Acknowledgments

This work was supported by a grant from the National R&D Program for Cancer Control, Ministry for Health and Welfare, Republic of Korea.

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Authors and Affiliations

  1. Department of Biomedical Materials Engineering, Kangwon National University, Chuncheon, 200-701, Republic of Korea

    Young Ju Son & Hyuk Sang Yoo

  2. Department of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon, Republic of Korea

    Woo Jin Kim

  3. Institute of Bioscience and Bioengineering, Kangwon National University, Chuncheon, Republic of Korea

    Hyuk Sang Yoo

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  1. Young Ju Son
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  2. Woo Jin Kim
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  3. Hyuk Sang Yoo
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Correspondence to Hyuk Sang Yoo.

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Son, Y.J., Kim, W.J. & Yoo, H.S. Therapeutic applications of electrospun nanofibers for drug delivery systems. Arch. Pharm. Res. 37, 69–78 (2014). https://doi.org/10.1007/s12272-013-0284-2

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  • DOI: https://doi.org/10.1007/s12272-013-0284-2

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