Skip to main content
Log in

Cytotoxic lignans from Viburnum foetidum

  • Research Article
  • Published:
Archives of Pharmacal Research Aims and scope Submit manuscript

Abstract

Two new lignans, 3,4,4′-trihydroxy-3′,9-dimethoxy-9,9′-epoxylignan (1), 3,4′-dihydroxy-3′,4, 9-trimethoxy-9,9′-epoxylignan (2), together with one known compound, 4,4′-dihydroxy-3,3′,9-trimethoxy-9,9′-epoxylignan (3), were isolated from the 95 % EtOH extract of Viburnum foetidum. The structures of the two new compounds were elucidated on the basis of 1D, 2D-NMR, and mass spectral analysis. All the lignans were in vitro evaluated for their cytotoxic activities against four tumor cell lines (A549, SK-OV-3, SKMEL-2 and HCT15).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  • Chen, X.Q., Y. Li, J. He, K. Wang, M.M. Li, Z.H. Pan, L.Y. Peng, X. Cheng, and Q.S. Zhao. 2009. Four new lignans from Viburnum foetidum var. foedidum. Chemical & Pharmaceutical Bulletin 57: 1129–1131.

    Article  CAS  Google Scholar 

  • Fukuyama, Y., H. Fujii, H. Minami, H. Takahashi, and M. Kubo. 2006. Neovibsanin F and its congeners, rearranged vibsane-type diterpenes from Viburnum suspensum. Journal of Natural Products 69: 1098–1100.

    Article  PubMed  CAS  Google Scholar 

  • Fukuyama, Y., H. Minami, R. Ichikawa, K. Takeuchi, and M. Kodama. 1996a. Hydroperoxylated guaiane-type sesquiterpenes from Viburnum awabuki. Phytochemistry 42: 741–744.

    Article  CAS  Google Scholar 

  • Fukuyama, Y., M. Nakahara, H. Minami, and M. Kodama. 1996b. Two Nnew benzofuran-type lignans from the wood of Viburnum awabuki. Chemical & Pharmaceutical Bulletin 44: 1418–1420.

    Article  CAS  Google Scholar 

  • Hase, T., T. Iwagawa, and M.N. Dave. 1985. Three iridoid glycosides from Viburnum furcatum. Phytochemistry 24: 1323–1327.

    Article  CAS  Google Scholar 

  • Kagawa, M., H. Minami, M. Nakahara, H. Takahashi, S. Takaoka, and Y. Fukuyama. 1998. Oleanane-type triterpenes from Viburnum awabuki. Phytochemistry 47: 1101–1105.

    CAS  Google Scholar 

  • Machida, K., and M. Kikuchi. 1996. Viburnols: novel triterpenoids with a rearranged dammarane skeleton from Viburnum dilatatum. Tetrahedron Letters 37: 4157–4159.

    Article  CAS  Google Scholar 

  • Sichaem, J., S. Surapinit, P. Siripong, S. Khumkratok, J. Jong-aramruang, and S. Tip-pyang. 2010. Two new cytotoxic isomeric indole alkaloids from the roots of Nauclea orientalis. Fitoterapia 81: 830–833.

    Article  PubMed  CAS  Google Scholar 

  • Wang, L.Q., Y.G. Chen, J.J. Xu, Y. Liu, X.M. Li, and Y. Zhao. 2008. Compounds from Viburnum species and their biological activities. Chemistry & Biodiversity 5: 1879–1899.

    Article  CAS  Google Scholar 

  • Xu, B.S., J.Q. Hu, and H.J. Wang. 1988a. In Flora Reipublicae Popularis Sinicae. Volume 72, ed. B.S. Xu, 56. Beijing: Science Press.

    Google Scholar 

  • Xu, B.S., J.Q. Hu, and H.J. Wang. 1988b. In Flora Reipublicae Popularis Sinicae. Volume 72, ed. B.S. Xu, 66. Beijing: Science Press.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yuanguo Luo.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Li, H., Luo, Y., Ma, Y. et al. Cytotoxic lignans from Viburnum foetidum . Arch. Pharm. Res. 36, 1211–1214 (2013). https://doi.org/10.1007/s12272-013-0218-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12272-013-0218-z

Keywords

Navigation