Abstract
Two new lignans, 3,4,4′-trihydroxy-3′,9-dimethoxy-9,9′-epoxylignan (1), 3,4′-dihydroxy-3′,4, 9-trimethoxy-9,9′-epoxylignan (2), together with one known compound, 4,4′-dihydroxy-3,3′,9-trimethoxy-9,9′-epoxylignan (3), were isolated from the 95 % EtOH extract of Viburnum foetidum. The structures of the two new compounds were elucidated on the basis of 1D, 2D-NMR, and mass spectral analysis. All the lignans were in vitro evaluated for their cytotoxic activities against four tumor cell lines (A549, SK-OV-3, SKMEL-2 and HCT15).
Similar content being viewed by others
References
Chen, X.Q., Y. Li, J. He, K. Wang, M.M. Li, Z.H. Pan, L.Y. Peng, X. Cheng, and Q.S. Zhao. 2009. Four new lignans from Viburnum foetidum var. foedidum. Chemical & Pharmaceutical Bulletin 57: 1129–1131.
Fukuyama, Y., H. Fujii, H. Minami, H. Takahashi, and M. Kubo. 2006. Neovibsanin F and its congeners, rearranged vibsane-type diterpenes from Viburnum suspensum. Journal of Natural Products 69: 1098–1100.
Fukuyama, Y., H. Minami, R. Ichikawa, K. Takeuchi, and M. Kodama. 1996a. Hydroperoxylated guaiane-type sesquiterpenes from Viburnum awabuki. Phytochemistry 42: 741–744.
Fukuyama, Y., M. Nakahara, H. Minami, and M. Kodama. 1996b. Two Nnew benzofuran-type lignans from the wood of Viburnum awabuki. Chemical & Pharmaceutical Bulletin 44: 1418–1420.
Hase, T., T. Iwagawa, and M.N. Dave. 1985. Three iridoid glycosides from Viburnum furcatum. Phytochemistry 24: 1323–1327.
Kagawa, M., H. Minami, M. Nakahara, H. Takahashi, S. Takaoka, and Y. Fukuyama. 1998. Oleanane-type triterpenes from Viburnum awabuki. Phytochemistry 47: 1101–1105.
Machida, K., and M. Kikuchi. 1996. Viburnols: novel triterpenoids with a rearranged dammarane skeleton from Viburnum dilatatum. Tetrahedron Letters 37: 4157–4159.
Sichaem, J., S. Surapinit, P. Siripong, S. Khumkratok, J. Jong-aramruang, and S. Tip-pyang. 2010. Two new cytotoxic isomeric indole alkaloids from the roots of Nauclea orientalis. Fitoterapia 81: 830–833.
Wang, L.Q., Y.G. Chen, J.J. Xu, Y. Liu, X.M. Li, and Y. Zhao. 2008. Compounds from Viburnum species and their biological activities. Chemistry & Biodiversity 5: 1879–1899.
Xu, B.S., J.Q. Hu, and H.J. Wang. 1988a. In Flora Reipublicae Popularis Sinicae. Volume 72, ed. B.S. Xu, 56. Beijing: Science Press.
Xu, B.S., J.Q. Hu, and H.J. Wang. 1988b. In Flora Reipublicae Popularis Sinicae. Volume 72, ed. B.S. Xu, 66. Beijing: Science Press.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Li, H., Luo, Y., Ma, Y. et al. Cytotoxic lignans from Viburnum foetidum . Arch. Pharm. Res. 36, 1211–1214 (2013). https://doi.org/10.1007/s12272-013-0218-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12272-013-0218-z