Abstract
Two new sesquiterpene pyridine alkaloids rugosusines A and B (1 and 2), and thirty-one known compounds were isolated from the stems of Celastrus rugosus. The structures of new compounds were elucidated by detailed spectroscopic analysis, including HR-ESI–MS and 2D NMR spectroscopic data. All the compounds were isolated from this plant for the first time. The cytotoxicities of these compounds were tested against SKOV3 and MGC-803 cell lines by CCK-8 method.
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Acknowledgments
The work was supported by program NCET Foundation, NSFC (81230090 and 81102778), partially supported by Global Research Network for Medicinal Plants (GRNMP) and King Saud University, Shanghai Leading Academic Discipline Project (B906), FP7-PEOPLE-IRSES-2008 (TCMCANCER Project 230232), Key laboratory of drug research for special environments, PLA, Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products (10DZ2251300) and the Scientific Foundation of Shanghai China (10DZ1971700, 12401900501). National Major Project of China (2011ZX09307-002-03 and 2011ZX09102-006-02). National Key Technology R&D Program of China (2012BAI29B06).
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Chang, R., Wang, C., Zeng, Q. et al. Chemical constituents of the stems of Celastrus rugosus . Arch. Pharm. Res. 36, 1291–1301 (2013). https://doi.org/10.1007/s12272-013-0145-z
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DOI: https://doi.org/10.1007/s12272-013-0145-z