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Abuse and dependence liability analysis of methylphenidate in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder (ADHD): what have we learned?

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An Erratum to this article was published on 30 April 2013

Abstract

Methylphenidate is the most prescribed stimulant medication for attention-deficit/hyperactivity disorder (ADHD). Despite the well documented clinical benefits of the drug, several questions remain unanswered concerning the effects of extended methylphenidate use (e.g. can methylphenidate be abused by ADHD patients? does repeated methylphenidate treatment produce addiction?). Preclinical studies can help address the long-term safety of clinical treatments, moreover animal studies provide valuable information on the details of drug actions. The spontaneously hypertensive rat (SHR), bred from normotensive Wistar Kyoto rat strain, is considered as the best validated and the most widely used animal model of ADHD. We reviewed the findings of research reports that investigated the abuse and dependence liability of methylphenidate in SHR. In particular, we surveyed the studies which investigated the effects of methylphenidate pretreatment on subsequent methylphenidate-induced conditioned place preference or self-administration for they may give insights into the abuse or dependence liability of long-term methylphenidate treatment in ADHD.

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Acknowledgments

The authors acknowledge financial supports from the Korea Healthcare technology R and D project, Ministry for Health and Welfare Affairs, Republic of Korea (grant number A120013) and Sahmyook University. We have no conflict of interest to declare.

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  1. Department of Pharmacy, Sahmyook University, 26-21 Kongreung-2-dong, Hwarangro-815, Nowon-gu, Seoul, 139-742, Korea

    Ike dela Peña & Jae Hoon Cheong

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  1. Ike dela Peña
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  2. Jae Hoon Cheong
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Correspondence to Jae Hoon Cheong.

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dela Peña, I., Cheong, J.H. Abuse and dependence liability analysis of methylphenidate in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder (ADHD): what have we learned?. Arch. Pharm. Res. 36, 400–410 (2013). https://doi.org/10.1007/s12272-013-0037-2

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  • DOI: https://doi.org/10.1007/s12272-013-0037-2

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