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Effect of sodium carboxymethylcellulose and fucidic acid on the gel characterization of polyvinylalcohol-based wound dressing

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Abstract

The purpose of this study was to investigate the effect of sodium carboxymethylcellulose (Na-CMC) and fucidic acid on the gel characterization for the development of sodium fucidate-loaded wound dressing. The cross-linked hydrogel films were prepared with polyvinyl alcohol (PVA) and sodium carboxymethylcellulose (Na-CMC) using the freeze-thawing method. Their gel properties such as gel fraction, swelling, water vapor transmission test, morphology, tensile strength and thermal property were investigated. In vitro protein adsorption test and release were performed. Na-CMC decreased the gel fraction and tensile strength of the hydrogels, but increased the swelling ability, water vapor transmission rate, elasticity and porosity of hydrogels. Thus, the wound dressing developed with PVA and Na-CMC was more swellable, flexible and elastic than that with only PVA because of its cross-linking interaction with PVA. However, the drug had a negative effect on the gel properties of hydrogels but there were no significant differences. In particular, the hydrogel composed of 2.5% PVA, 1.125% Na-CMC and 0.2% drug might give an adequate level of moisture and build up the exudates on the wound area. Thus, this sodium fucidate-loaded hydrogel could be a potential candidate for wound dressing with excellent forming.

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Authors and Affiliations

  1. Department of Bioscience and Biotechnology of Life Sciences and Biotechnology, Sejong University, Seoul, 143-747, Korea

    Soo-Jeong Lim, Dong Hoon Oh & Du Hyung Hwang

  2. College of Pharmacy, Yeungnam University, Gyongsan, 712-749, Korea

    Jeong Hoon Lee, Chul Soon Yong & Han-Gon Choi

  3. Department of Pharmaceutical Sciences, College of Pharmacy, Yanbian University, Juzi Street, Yanji City, Jilin Province, 133000, China

    Ming Guan Piao

  4. College of Pharmacy, Woo Suk University, Gyongsan, 565-701, Korea

    Mi-Kyung Lee

  5. Biochemical Engineering College, Beijing Union University, No.18, 3rd Section, Fatouxili, Chaoyang District, Beijing, 100023, China

    Qi Zhe Quan

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  1. Soo-Jeong Lim
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Correspondence to Chul Soon Yong or Han-Gon Choi.

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Lim, SJ., Lee, J.H., Piao, M.G. et al. Effect of sodium carboxymethylcellulose and fucidic acid on the gel characterization of polyvinylalcohol-based wound dressing. Arch. Pharm. Res. 33, 1073–1081 (2010). https://doi.org/10.1007/s12272-010-0714-3

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  • DOI: https://doi.org/10.1007/s12272-010-0714-3

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