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The inhibitory effect of ginseng pectin on L-929 cell migration

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Abstract

We tested the effects of ginseng pectin prepared by enzymatic hydrolysis of ginseng polysaccharides on cell migration. Ginseng pectin impaired the migration of L-929 cells and reduced their migration speed by up to 50% of control in the presence or absence of serum, suggesting it worked on both serum-dependent and serum-independent migration pathways. Ginseng pectin impaired cell migration via decreased cell spreading. These findings represent a significant contribution towards understanding the bioactivities of ginseng polysaccharides and applying them to health food and medicine.

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Authors and Affiliations

  1. School of Life Sciences, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin Province, 130024, China

    Yuying Fan, Hairong Cheng, Dan Liu, Xu Zhang, Bo Wang, Lin Sun, Guihua Tai & Yifa Zhou

  2. College of Chemistry and Biology, Beihua University, 3999 Huabei Road, Jilin City, Jilin Province, 132013, China

    Bo Wang

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  1. Yuying Fan
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  2. Hairong Cheng
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  3. Dan Liu
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  4. Xu Zhang
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  5. Bo Wang
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  6. Lin Sun
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  7. Guihua Tai
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  8. Yifa Zhou
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Correspondence to Guihua Tai or Yifa Zhou.

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Fan, Y., Cheng, H., Liu, D. et al. The inhibitory effect of ginseng pectin on L-929 cell migration. Arch. Pharm. Res. 33, 681–689 (2010). https://doi.org/10.1007/s12272-010-0506-9

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  • DOI: https://doi.org/10.1007/s12272-010-0506-9

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