Abstract
Effects of wogonin analogs on cyclooxygenase-2 (COX-2) catalyzed prostaglandin E2 production on lipopolysaccharide (LPS)-induced RAW 264.7 cells were investigated. Wogonin analogs were prepared via several different synthetic pathways. Among wogonin analogs tested, 8-halogeno and 8-nitro analogs showed strong inhibitory activities against COX-2 catalyzed PGE2 production from LPS-induced RAW 264.7 cells. Effect of wogonin was largely dependent on structural alteration of the 8-methoxy group.
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Gurung, S.K., Kim, H.P. & Park, H. Inhibition of prostaglandin E2 production by synthetic Wogonin analogs. Arch. Pharm. Res. 32, 1503–1508 (2009). https://doi.org/10.1007/s12272-009-2101-5
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DOI: https://doi.org/10.1007/s12272-009-2101-5