Abstract
A number of 8-arylflavones have been synthesized as congeners of wogonin and evaluated for their inhibitory activities of PGE2 production. 8-Arylflavones were obtained from commercially available chrysin via two different synthetic pathways. Most 8-arylflavones exhibited much reduced inhibitory activities against COX-2 catalyzed PGE2 production compared to that of wogonin. Functional group replacement at the 8-position of wogonin from methoxy to aryl group caused loss of inhibitory activity. Our present results imply that the functional group at the 8-position of flavones seems to play very important roles for bioactivity.
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Dao, T.T., Kim, S.B., Sin, KS. et al. Synthesis and biological activities of 8-arylflavones. Arch Pharm Res 27, 278–282 (2004). https://doi.org/10.1007/BF02980059
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DOI: https://doi.org/10.1007/BF02980059