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Role of protein tyrosine nitration in neurodegenerative diseases and atherosclerosis

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Abstract

Nitric oxide generates reactive nitrosative species, such as peroxynitrite (ONOO−) that may be involved in a number of diseases. ONOO− can mediate protein tyrosine nitration which causes structural changes of affected proteins and leads to their inactivation. Various proteomics and immunological methods including mass spectrometry combined with both liquid and 2-D PAGE, and immunodetection have been employed to identify and characterize nitrated proteins from pathological samples. This review presents the pahtobiological roles of the pathogenic posttranslational modification in neurodegenerative diseases and atherosclerosis.

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  1. Department of Molecular Biotechnology, Konkuk University, Seoul, 143-701, Korea

    Jung Rok Lee, Jae Kyung Kim & Kwang Pyo Kim

  2. Institute of Biomedical Science and Technology, Konkuk University, Seoul, 143-701, Korea

    Kwang Pyo Kim

  3. Probiond Co., Ltd., Gwangjin VBS Center, Seoul, 143-834, Korea

    Soo Jae Lee

  4. Department of Molecular Biotechnology and Institute of Biomedical Science and Technology, Konkuk University, Seoul, 143-701, Korea

    Kwang Pyo Kim

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Lee, J.R., Kim, J.K., Lee, S.J. et al. Role of protein tyrosine nitration in neurodegenerative diseases and atherosclerosis. Arch. Pharm. Res. 32, 1109–1118 (2009). https://doi.org/10.1007/s12272-009-1802-0

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