Abstract
A new spiroketal, spirodienal B (1), was isolated from culture extracts of S. cellulosum. Its structure was elucidated by spectroscopic analysis. In addition to 1, the strain produced a second, closely related antibiotic, spirodienal. Both compounds demonstrated potent cytotoxicity against human tumor cells. Against human tumor cells such as HCT-15, the activity of 1 was more than 4000 times stronger than that of doxorubicin in terms of IC50.
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Kwak, J.H., Ahn, JW. A new cytotoxic spiroketal from the myxobacterium Sorangium cellulosum . Arch. Pharm. Res. 32, 841–844 (2009). https://doi.org/10.1007/s12272-009-1604-4
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DOI: https://doi.org/10.1007/s12272-009-1604-4