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Function of CD147 in Atherosclerosis and Atherothrombosis

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Abstract

CD147, a member of the immunoglobulin super family, is a well-known potent inducer of extracellular matrix metalloproteinases. Studies show that CD147 is upregulated in inflammatory diseases. Atherosclerosis is a chronic inflammatory disease of the artery wall. Further understanding of the functions of CD147 in atherosclerosis and atherothrombosis may provide a new strategy for preventing and treating cardiovascular disease. In this review, we discuss how CD147 contributes to atherosclerosis and atherothrombosis.

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Acknowledgments

This project was supported by the Development Health Engineering of Jiangsu Province (No. LJ201116), the National Natural Science Foundation of China (Nos. 81400269 and 81370409), the Key Laboratory of Cardiovascular Disease of Zhenjiang (No. SS2012002), and the National Institutes of Health (Grant No. R01NS088719; GL).

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No human studies were carried out by the authors for this article.

No animal studies were carried out by the authors for this article.

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Authors and Affiliations

  1. Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu province, People’s Republic of China, 212001

    Cuiping Wang & Jinchuan Yan

  2. Department of Neurosurgery, LSU Health Science Center, Shreveport, LA, 71103, USA

    Cuiping Wang, Rong Jin, Xiaolei Zhu & Guohong Li

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  1. Cuiping Wang
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Correspondence to Jinchuan Yan or Guohong Li.

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Editor-in-Chief Jennifer L. Hall oversaw the review of this article.

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Wang, C., Jin, R., Zhu, X. et al. Function of CD147 in Atherosclerosis and Atherothrombosis. J. of Cardiovasc. Trans. Res. 8, 59–66 (2015). https://doi.org/10.1007/s12265-015-9608-6

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