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Tunicate Cellulose Nanocrystals as Stabilizers for PLGA-based Polymeric Nanoparticles

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  • Nanobiotechnology
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Abstract

Nanoparticles have different physical and chemical properties than those of micro-sized particles and are actively studied in the fields of electronics, biology, and material science. However, in case of most polymeric nanoparticles, maintaining and remaining in their colloid state for a long time is difficult due to self-aggregation. In this study, we examined the morphological, physical, and chemical properties of tunicate cellulose nanocrystals (tCNC) and also investigated the effect of tCNC on colloidal behaviors of poly(lactic-co-glycolic acid) (PLGA)-based nanoparticles. Fourier-transform infrared spectroscopy (FTIR) showed that tCNC do not have a chemical effect on PLGA-based nanoparticles. Dynamic light scattering (DLS) showed that tCNC helped the PLGA nanoparticles maintain their small sizes for a longer period in solution. tCNC were also confirmed to be non-cytotoxic to human dermal fibroblasts at concentrations below 0.5%. Based on these results, tCNC were found to be a stabilizer for PLGA-based nanoparticles.

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Acknowledgements

This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF-2019 R1A2C1085319) and INHA UNIVERSITY RESEARCH GRANT.

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  1. Department of Biological Engineering, Inha University, Incheon, 22212, Korea

    Sang Yoon Jun, Jongho Park, Hyeongi Song & Hwasung Shin

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Jun, S.Y., Park, J., Song, H. et al. Tunicate Cellulose Nanocrystals as Stabilizers for PLGA-based Polymeric Nanoparticles. Biotechnol Bioproc E 25, 206–214 (2020). https://doi.org/10.1007/s12257-019-0379-9

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