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Undaria pinnatifida fucoidan extract protects against CCl4-induced oxidative stress

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Abstract

This study was performed to elucidate the effects of Undaria pinnatifida fucoidan extract (UPFE) in preventing CCl4-induced oxidative stress. UPFE (100 mg/kg) was intraperitoneally administered to rats for 14 days. On day 15, CCl4 dissolved in olive oil (50% CCl4) was injected 12 h before they were anesthetized and dissected. To measure UPFE-mediated antioxidation, we examined the levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) in serum, as well as malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in liver homogenates. CCl4 treatment markedly increased the levels of GOT, GPT, ALP, LDH, and MDA and significantly decreased levels of SOD, CAT, and GPx. UPFE pretreatment decreased levels of GOT, GPT, ALP, LDH, and MDA, by 62.8, 68.5, 41.9, 72.7, and 122%, respectively and increased those of SOD, CAT, and GPx by 111.1, 15.9, and 52.6%, respectively. These results showed that UPFE has antioxidant effects against CCl4-induced oxidative stress.

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Authors and Affiliations

  1. Department of Pharmaceutical Engineering, College of Medical Life Science, Silla University, Busan 617-736, Korea

    Kum Suk Kang, In Deok Kim, Ryun Hee Kwon & Bae Jin Ha

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  1. Kum Suk Kang
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  2. In Deok Kim
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  3. Ryun Hee Kwon
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  4. Bae Jin Ha
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Correspondence to Bae Jin Ha.

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Kang, K.S., Kim, I.D., Kwon, R.H. et al. Undaria pinnatifida fucoidan extract protects against CCl4-induced oxidative stress. Biotechnol Bioproc E 13, 168–173 (2008). https://doi.org/10.1007/s12257-007-0101-1

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  • DOI: https://doi.org/10.1007/s12257-007-0101-1

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