Skip to main content
SpringerLink
Log in

B7-H6 Protein Expression has no Prognostic Significance in Human Gastric Carcinoma

  • Research
  • Published:
Pathology & Oncology Research

Abstract

B7-H6, a novel member of the B7 family which binds to NKp30 to trigger antitumor NK cell cytotoxicity and cytokine secretion. Recently, B7-H family has been reported to be a negative regulator of the immune response in patients with gastric carcinoma. However, no reports have investigated the clinical significance of B7-H6 expression in human gastric cancer. We present the first study to the clinicopathological and prognostic value of B7-H6 in primary gastric tumors and adjacent non-tumor tissues at the protein level. Here we show that B7-H6 immunoreactivity was expressed in 6/60 (10 %) gastric tumors and 8/43 (18.60 %) adjacent non-tumor tissues. No statistical difference was found between B7-H6 expression and various prognostic factors; however, B7-H6-positive carcinomas were significantly associated with a higher differentiation (p = 0.047). The survival analysis did not confirm the prognostic significance of B7-H6 expression in gastric cancer patients. Our data suggest that B7-H6, as detected by immunohistochemistry, is of limited value as a prognostic marker for gastric cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer Clin 61:69–90. doi:10.3322/caac

    Article  Google Scholar 

  2. Zang X, Allison JP (2007) The B7 family and cancer therapy. Costimulation and coinhibition. Clin Cancer Res 13:5271–5279

    Article  CAS  PubMed  Google Scholar 

  3. Greaves P, Gribben JG (2013) The role of B7 family molecules in hematologic malignancy. Blood 121:734–744. doi:10.1182/blood-2012-10-385591

    Article  CAS  PubMed  Google Scholar 

  4. Lu B, Chen L, Liu L, Zhu Y, Wu C, Jiang J, Zhang X (2011) T-cell-mediated tumor immune surveillance and expression of B7 co-inhibitory molecules in cancers of the upper gastrointestinal tract. Immunol Res 50:269–275. doi:10.1007/s12026-011-8227-9

    Article  CAS  PubMed  Google Scholar 

  5. Capece D, Verzella D, Fischietti M, Zazzeroni F, Alesse E (2012) Targeting costimulatory molecules toimprove antitumor immunity. J Biomed Biotechnol 2012:926321. doi:10.1155/2012/926321

    Article  PubMed Central  PubMed  Google Scholar 

  6. Seliger B, Quandt D (2012) The expression, function, and clinical relevance of B7 family members in cancer. Cancer Immunol Immunother 61:1327–1341. doi:10.1007/s00262-012-1293-6

    Article  CAS  PubMed  Google Scholar 

  7. Brandt CS, Baratin M, Yi EC, Kennedy J, Gao Z, Fox B, Haldeman B, Ostrander CD, Kaifu T, Chabannon C, Moretta A, West R, Xu W, Vivier E, Levin SD (2009) The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans. J Exp Med 206:1495–1503. doi:10.1084/jem.20090681

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  8. Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A (2009) AJCC cancer staging manual, 7th edn. Springer-verlag, New York

    Google Scholar 

  9. Wu C, Zhu Y, Jiang J, Zhao J, Zhang XG, Xu N (2006) Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance. Acta Histochem 108:19–24

    Article  PubMed  Google Scholar 

  10. Liu SM, Meng Q, Zhang QX (2008) Expression and significance of B7-H1 and its receptor PD-1 in human gastric carcinoma. Zhonghua Zhong Liu Za Zhi 30:192–195

    CAS  PubMed  Google Scholar 

  11. Sun J, Xu K, Wu C, Wang Y, Hu Y, Zhu Y, Chen Y, Shi Q, Yu G, Zhang X (2007) PD-L1 expression analysis in gastric carcinoma tissue and blocking of tumor-associated PD-L1 signaling by two functional monoclonal antibodies. Tissue Antigens 69:19–27

    Google Scholar 

  12. Wu CP, Jiang JT, Tan M, Zhu YB, Ji M, Xu KF, Zhao JM, Zhang GB, Zhang XG (2006) Relationship between co-stimulatory molecule B7-H3 expression and gastric carcinoma histology and prognosis. World J Gastroenterol 12:457–459

    Google Scholar 

  13. Arigami T, Uenosono Y, Hirata M, Yanagita S, Ishigami S, Natsugoe S (2011) B7-H3 expression in gastric cancer: a novel molecular blood marker for detecting circulating tumor cells. Cancer Sci 102:1019–1024. doi:10.1111/j.1349-7006.2011.01877.x

    Article  CAS  PubMed  Google Scholar 

  14. Arigami T, Uenosono Y, Ishigami S, Hagihara T, Haraguchi N, Natsugoe S (2011) Clinical significance of the B7-H4 coregulatory moleculeas a novel prognostic marker in gastric cancer. World J Surg 35:2051–2057. doi:10.1007/s00268-011-1186-4

    Article  PubMed  Google Scholar 

  15. Jiang J, Zhu Y, Wu C, Shen Y, Wei W, Chen L, Zheng X, Sun J, Lu B, Zhang X (2010) Tumor expression of B7-H4 predicts poor survival of patients suffering from gastric cancer. Cancer Immunol Immunother 59:1707–1714

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

The authors thank the patients who took part in this study. Work was supported by the National Natural Science Foundation of China (No. 30872943).

Conflict of interest

All the authors declare no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China

    Xiao-Juan Chen, Jin Shen, Guang-Bo Zhang & Wei-Chang Chen

  2. Key Laboratory of Medicine and Clinical Immunology of Jiangsu Province, Suzhou, 215006, China

    Guang-Bo Zhang & Wei-Chang Chen

Authors
  1. Xiao-Juan Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jin Shen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Guang-Bo Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Wei-Chang Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Wei-Chang Chen.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chen, XJ., Shen, J., Zhang, GB. et al. B7-H6 Protein Expression has no Prognostic Significance in Human Gastric Carcinoma. Pathol. Oncol. Res. 20, 203–207 (2014). https://doi.org/10.1007/s12253-013-9686-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12253-013-9686-1

Keywords

Search

Navigation