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Polymorphisms of the XRCC1 and XPD Genes and Breast Cancer Risk: A Case-Control Study

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Pathology & Oncology Research

Abstract

The purpose of this case control study was to evaluate the role of X-ray repair cross-complementing group 1 (XRCC1) and xeroderma pigmentosum group D (XPD) genotypes as genetic indicators of susceptibility to breast cancer (BC). We analysed DNA samples from 114 breast cancer patients and 113 control subjects using polymerase chain reaction–restriction fragment length polymorphism. For the single nucleotide polymorphisms in XRCC1 exon 10 (Arg399Gln, G/A) and XPD exon 23 (Lys751Gln, A/C), no remarkable differences for genotype distribution and allele frequencies were observed between BC group and control group in the study. The genotype frequency for homozygote A/A in XPD exon 6 (Arg156Arg, C/A) were significantly different between BC and control groups (P < 0.0001, odds ratio = 2.14; 95% confidence interval 1.44–3.17). The data indicate a possible role for XPD (Arg156Arg, C/A) polymorphisms in BC susceptibility.

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Acknowledgements

This research was supported in part by the Ministry of Health of the Slovak Republic (grant No. 2005/46-VOUKE-01 and by the Slovak Grant Agency for Science (VEGA grant No. 1/3372/06). We would like to thank Erik Biroš, Ph.D. for his help with the design of the experiments.

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine, P.J. Šafárik University, 040 11, Košice, Slovak Republic

    Lívia Kipikašová, Tomáš Wolaschka, Ladislav Mirossay, Marek Šarišský, Andrej Miroššay, Martina Čižmáriková & Ján Mojžiš

  2. Department of Pathology, University Hospital, Košice, Slovak Republic

    Peter Bohuš & Helena Baumohlová

  3. 1st Surgery Department, Faculty of Medicine, P.J. Šafárik University, Košice, Slovak Republic

    Juraj Bober & Jana Blažejová

  4. Department of Informatics, Faculty of Medicine, P.J. Šafárik University, Košice, Slovak Republic

    Dana Potočeková

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  1. Lívia Kipikašová
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  2. Tomáš Wolaschka
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Correspondence to Ján Mojžiš.

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Kipikašová, L., Wolaschka, T., Bohuš, P. et al. Polymorphisms of the XRCC1 and XPD Genes and Breast Cancer Risk: A Case-Control Study. Pathol. Oncol. Res. 14, 131–135 (2008). https://doi.org/10.1007/s12253-008-9034-z

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  • DOI: https://doi.org/10.1007/s12253-008-9034-z

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