Abstract
Laribacter hongkongensis is relatively a new name in the list of bacterial pathogens for gastroenteritis and travelers’ diarrhea. Addition of another name increases burden on the enteric infections as a whole. L. hongkongensis belongs to Neisseriaceae family of β subclass Proteobacteria. L. hongkongensis was initially isolated in Hong Kong from blood and empyema of an alcoholic cirrhotic patient in 2001, followed by reports from Korea and China, representing a total of 38 articles in PubMed until April 2013. As of now, there is no report from Indian subcontinent where infectious diarrhea is very much prevalent and a major burden. This review provides information about the microbiological characteristics, consideration of an emerging pathogen, relative pathogenicity, genome and proteome content, resistance toward multiple antibiotics, adaptability to different stress, and other features since its time of discovery. Investigation for this bacterium may avoid misidentification as other microbial flora. Further studies like the geographical distribution, type of infection, disease burden, pathogenicity, or genomic exploration of this bacterium will be useful in characterizing them properly. This bacterium may possibly be the emerging threat to public health.
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References
Bryce J, Boschi-Pinto C, Shibuya K, Black RE (2005) WHO estimates of the causes of death in children. Lancet 365(9465):1147–1152. doi:10.1016/s0140-6736(05)71877-8
Curreem SO, Teng JL, Tse H, Yuen KY, Lau SK, Woo PC (2011) General metabolism of Laribacter hongkongensis: a genome-wide analysis. Cell Biosci 1(1):16. doi:10.1186/2045-3701-1-16
Feng JL, Yan H, Chowdhury N, Neogi SB, Yamasaki S, Shi L, Hu J, Chen Q (2011) Identification and characterization of integron-associated antibiotic resistant Laribacter hongkongensis isolated from aquatic products in China. Int J Food Microbiol 144(3):337–341. doi:10.1016/j.ijfoodmicro.2010.10.014
Feng JL, Hu J, Lin JY, Liu S, Chowdhury N, Zhang O, Li JD, Shi L, Yamasaki S, Chen Q (2012) The prevalence, antimicrobial resistance and PFGE profiles of Laribacter hongkongensis in retail freshwater fish and edible frogs of southern China. Food Microbiol 32(1):118–123. doi:10.1016/j.fm.2012.04.018
Ghosh AR, Sehgal SC (1998) Detection of tdh and trh genes in a urea-hydrolysing environmental isolate of Vibrio parahaemolyticus from the Andamans. J Diarrhoeal Dis Res 16(2):87–90
Ghosh AR, Nair GB, Naik TN, Paul M, Pal SC, Sen D (1992) Entero-adherent Escherichia coli is an important diarrhoeagenic agent in infants aged below 6 months in Calcutta, India. J Med Microbiol 36(4):264–268
Kim DS, Wi YM, Choi JY, Peck KR, Song JH, Ko KS (2011) Bacteremia caused by Laribacter hongkongensis misidentified as Acinetobacter lwoffii: report of the first case in Korea. J Korean Med Sci 26(5):679–681. doi:10.3346/jkms.2011.26.5.679
Lau SK, Woo PC, Hui WT, Li MW, Teng JL, Que TL, Luk WK, Lai RW, Yung RW, Yuen KY (2003) Use of cefoperazone MacConkey agar for selective isolation of Laribacter hongkongensis. J Clin Microbiol 41(10):4839–4841
Lau SK, Ho PL, Li MW, Tsoi HW, Yung RW, Woo PC, Yuen KY (2005) Cloning and characterization of a chromosomal class C beta-lactamase and its regulatory gene in Laribacter hongkongensis. Antimicrob Agents Chemother 49(5):1957–1964. doi:10.1128/AAC.49.5.1957-1964.2005
Lau SK, Woo PC, Fan RY, Ma SS, Hui WT, Au SY, Chan LL, Chan JY, Lau AT, Leung KY, Pun TC, She HH, Wong CY, Wong LL, Yuen KY (2007) Isolation of Laribacter hongkongensis, a novel bacterium associated with gastroenteritis, from drinking water reservoirs in Hong Kong. J Appl Microbiol 103(3):507–515. doi:10.1111/j.1365-2672.2006.03263.x
Lau SK, Wong GK, Li MW, Woo PC, Yuen KY (2008) Distribution and molecular characterization of tetracycline resistance in Laribacter hongkongensis. J Antimicrob Chemother 61(3):488–497. doi:10.1093/jac/dkm539
Lau SK, Lee LC, Fan RY, Teng JL, Tse CW, Woo PC, Yuen KY (2009a) Isolation of Laribacter hongkongensis, a novel bacterium associated with gastroenteritis, from Chinese tiger frog. Int J Food Microbiol 129(1):78–82. doi:10.1016/j.ijfoodmicro.2008.10.021
Lau SK, Wong GK, Poon RW, Lee LC, Leung KW, Tse CW, Ho PL, Que TL, Woo PC, Yuen KY (2009b) Susceptibility patterns of clinical and fish isolates of Laribacter hongkongensis: comparison of the Etest, disc diffusion and broth microdilution methods. J Antimicrob Chemother 63(4):704–708. doi:10.1093/jac/dkp010
Lau SK, Woo PC, Yuen KY (2010) Multi-locus sequence typing scheme for Laribacter hongkongensis, a novel bacterium associated with freshwater fish-borne gastroenteritis and traveler’s diarrhoea. Hong Kong Med J 16(5 Suppl 4):13–14
Lau SK, Fan RY, Wong GK, Teng JL, Sze KH, Tse H, Yuen KY, Woo PC (2011a) Transport genes and chemotaxis in Laribacter hongkongensis: a genome-wide analysis. Cell Biosci 1:28. doi:10.1186/2045-3701-1-28
Lau SK, Wong GK, Tsang AK, Teng JL, Fan RY, Tse H, Yuen KY, Woo PC (2011b) Virulence determinants, drug resistance and mobile genetic elements of Laribacter hongkongensis: a genome-wide analysis. Cell Biosci 1(1):17. doi:10.1186/2045-3701-1-17
Lau SK, Fan RY, Ho TC, Wong GK, Tsang AK, Teng JL, Chen W, Watt RM, Curreem SO, Tse H, Yuen KY, Woo PC (2011c) Environmental adaptability and stress tolerance of Laribacter hongkongensis: a genome-wide analysis. Cell Biosci 1(1):22. doi:10.1186/2045-3701-1-22
Marcos LA, DuPont HL (2007) Advances in defining etiology and new therapeutic approaches in acute diarrhea. J Infect 55(5):385–393. doi:10.1016/j.jinf.2007.07.016
Ni XP, Ren SH, Sun JR, Xiang HQ, Gao Y, Kong QX, Cha J, Pan JC, Yu H, Li HM (2007) Laribacter hongkongensis isolated from a patient with community-acquired gastroenteritis in Hangzhou City. J Clin Microbiol 45(1):255–256. doi:10.1128/JCM.01400-06
Ni X, Sun J, Kong Q, Kong F, Brown M, Shen L, Cha J, Xiang H, Xu H, Jin H (2011) Isolation of Laribacter hongkongensis from Little Egrets (Egretta garzetta) in Hangzhou, China. Lett Appl Microbiol 52(5):465–467. doi:10.1111/j.1472-765X.2011.03024.x
Paul M, Tsukamoto T, Ghosh AR, Bhattacharya SK, Manna B, Chakrabarti S, Nair GB, Sack DA, Sen D, Takeda Y (1994) The significance of enteroaggregative Escherichia coli in the etiology of hospitalized diarrhoea in Calcutta, India and the demonstration of a new honey-combed pattern of aggregative adherence. FEMS Microbiol Lett 117(3):319–325
Petti CA, Polage CR, Schreckenberger P (2005) The role of 16S rRNA gene sequencing in identification of microorganisms misidentified by conventional methods. J Clin Microbiol 43(12):6123–6125. doi:10.1128/JCM.43.12.6123-6125.2005
Shen L, Xiao M, Kong F, Brown M, Sun J, Kong Q, Cha J, Xiang H, Xu H, Jin H, Wei L, Ni X (2011) Detection of Laribacter hongkongensis using species-specific duplex PCR assays targeting the 16S rRNA gene and the 16S-23S rRNA intergenic spacer region (ISR). J Appl Microbiol 111(3):625–630. doi:10.1111/j.1365-2672.2011.05083.x
Subhraveti P, Ong Q, Altman T, Keseler I, Shearer A, Caspi R, Karp PD, International S. Summary of Laribacter hongkongensis, Strain HLHK9, version 16.1 http://biocyc.org/organism-summary?object=LHON557598. Accessed 19 December 2013
Tang BS, Lau SK, Teng JL, Chan TM, Chan WS, Wong TY, Tong YT, Fan RY, Yuen KY, Woo PC (2013) Matrix-assisted laser desorption ionisation-time of flight mass spectrometry for rapid identification of Laribacter hongkongensis. J Clin Pathol 66(12):1081–1083. doi:10.1136/jclinpath-2013-201651
Teng JL, Woo PC, Ma SS, Sit TH, Ng LT, Hui WT, Lau SK, Yuen KY (2005) Ecoepidemiology of Laribacter hongkongensis, a novel bacterium associated with gastroenteritis. J Clin Microbiol 43(2):919–922. doi:10.1128/JCM.43.2.919-922.2005
Woo PC, Kuhnert P, Burnens AP, Teng JL, Lau SK, Que TL, Yau HH, Yuen KY (2003) Laribacter hongkongensis: a potential cause of infectious diarrhea. Diagn Microbiol Infect Dis 47(4):551–556
Woo PC, Lau SK, Teng JL, Que TL, Yung RW, Luk WK, Lai RW, Hui WT, Wong SS, Yau HH, Yuen KY, group LHs (2004) Association of Laribacter hongkongensis in community-acquired gastroenteritis with travel and eating fish: a multicentre case-control study. Lancet 363(9425):1941–1947. doi:10.1016/S0140-6736(04)16407-6
Woo PC, Lau SK, Teng JL, Yuen KY (2005) Current status and future directions for Laribacter hongkongensis, a novel bacterium associated with gastroenteritis and traveler’s diarrhoea. Curr Opin Infect Dis 18(5):413–419
Woo PC, Ma SS, Teng JL, Li MW, Lau SK, Yuen KY (2007a) Plasmid profile and construction of a small shuttle vector in Laribacter hongkongensis. Biotechnol Lett 29(10):1575–1582. doi:10.1007/s10529-007-9447-x
Woo PC, Teng JL, Ma SS, Lau SK, Yuen KY (2007b) Characterization of a novel cryptic plasmid, pHLHK26, in Laribacter hongkongensis. New Microbiol 30(2):139–147
Woo PC, Lau SK, Tse H, Teng JL, Curreem SO, Tsang AK, Fan RY, Wong GK, Huang Y, Loman NJ, Snyder LA, Cai JJ, Huang JD, Mak W, Pallen MJ, Lok S, Yuen KY (2009) The complete genome and proteome of Laribacter hongkongensis reveal potential mechanisms for adaptations to different temperatures and habitats. PLoS Genet 5(3):e1000416. doi:10.1371/journal.pgen.1000416
Woo PC, Yuen KY, Lau SK, Tse H (2010) Random exploration of the Laribacter hongkongensis genome. Hong Kong Med J 16(5 Suppl 4):15–17
Yang W, Chen WY, Wang H, Ho JW, Huang JD, Woo PC, Lau SK, Yuen KY, Zhang Q, Zhou W, Bartlam M, Watt RM, Rao Z (2011) Structural and functional insight into the mechanism of an alkaline exonuclease from Laribacter hongkongensis. Nucleic Acids Res 39(22):9803–9819. doi:10.1093/nar/gkr660
Yuen KY, Woo PC, Teng JL, Leung KW, Wong MK, Lau SK (2001) Laribacter hongkongensis gen. nov., sp. nov., a novel gram-negative bacterium isolated from a cirrhotic patient with bacteremia and empyema. J Clin Microbiol 39(12):4227–4232. doi:10.1128/JCM.39.12.4227-4232.2001
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Authors are grateful to the VIT management, VIT University, Vellore for pursuing the research.
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Raja, M.K., Ghosh, A.R. Laribacter hongkongensis: an emerging pathogen of infectious diarrhea. Folia Microbiol 59, 341–347 (2014). https://doi.org/10.1007/s12223-013-0299-6
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DOI: https://doi.org/10.1007/s12223-013-0299-6