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Cerebrospinal fluid and serum prealbumin (transthyretin) in patients with multiple sclerosis (MS): Comparison of particular subgroups of MS patients

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Abstract

The levels of prealbumin (PAB, transthyretin) were determined and evaluated in the cerebrospinal fluid (CSF) and serum in various subgroups of the multiple sclerosis (MS) patients. In severely disabled patients, serum PAB was elevated more frequently. CSF and serum PAB concentrations were higher in treated than in nontreated patients; the values above the upper reference limits were also more frequently found in treated patients. PAB index showed a tendency to decrease during the course of the disease. The routine determination of PAB in CSF and serum is, therefore, recommended to be recognized in MS patients as a substantial clinical value and, thus, be comprised, including also immunoglobulins and other parameteres, into the spectrum of characteristics in Protein Pannel.

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Abbreviations

Alb:

albumin

CSF:

cerebrospinal fluid

MS:

multiple sclerosis

PAB:

prealbumin

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Authors and Affiliations

  1. Laboratory of Reference for CSF and Neuroimmunology, Department of Clinical Biochemistry, Homolka Hospital, Prague, Czech Republic

    M. Hybeľová

  2. Department of Neurology, RHG City Hospital, Kralupy n.Vlt., Czech Republic

    J. Svatoňová

  3. Laboratory for CSF and Neuroimmunology, Central Military Hospital Complex, Prague, Czech Republic

    O. Sobek, P. Adam & D. Adam

  4. Department of Neurology, 3rd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic

    D. Doležil

  5. Reference Laboratory CSF, Topelex Ltd., Central Military Hospital Complex — F1, U Vojenské nemocnice 1200, 162 00, Prague 6, Czech Republic

    D. Adam

Authors
  1. M. Hybeľová
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  2. J. Svatoňová
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  3. O. Sobek
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  4. P. Adam
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  5. D. Doležil
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  6. D. Adam
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Correspondence to D. Adam.

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Hybeľová, M., Svatoňová, J., Sobek, O. et al. Cerebrospinal fluid and serum prealbumin (transthyretin) in patients with multiple sclerosis (MS): Comparison of particular subgroups of MS patients. Folia Microbiol 54, 173–176 (2009). https://doi.org/10.1007/s12223-009-0027-4

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  • DOI: https://doi.org/10.1007/s12223-009-0027-4

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