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Potential Use of Electrospun Poly(ethylene terephthalate)/Carbon Nanotubes Containing Aspirin in Vascular Tissue Engineering Application

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Abstract

In the field of vascular tissue engineering, the incorporation of anticoagulant drugs into polymeric nanofibers is a key strategy to enhance performance and prevent thrombosis. This study focuses on preparation of electro-spun poly(ethylene terephthalate) (PET)/carboxylated multi-walled carbon nanotubes (MWCNTs) nanofibers containing aspirin (Asp) as potential vascular substitutes. Various tests, including SEM, FTIR, tensile strength, electrical conductivity, water contact angle, UV–visible, hemo-compatibility, and cell culture assessments, are conducted. The SEM images show an average diameter of approximately 166 nm with a smooth surface for PET/MWCNT nanofibers with 10 wt.% PET and 1 wt.% MWCNT. The FTIR results indicate the presence of MWCNT in the nanofibers, with no significant chemical interaction. The electrical conductivity and WCA are measured at 4.08 × 10–10 S/cm and 120°, respectively. The tensile test reveals an increase in Young’s modulus from 14.6 to 36.6 MPa after MWCNT addition. The inclusion of MWCNT results in an increase of Asp release up to 37%, following the Higuchi model. PET/MWCNT nanofibers reduce platelet adhesion and extend PTT time (up to 40 s) as well as remain hemolysis below 5% compared to PET. This work underscores the potential of electro-spun PET/MWCNT nanofibers with Asp for vascular substitutes.

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The data supporting the findings of this study are available within the article and/or from the authors upon reasonable request.

References

  1. M. Zhang, S. Xu, R. Wang, Y. Che, C. Han, W. Feng, C. Wang, W. Zhao, J. Mater. Sci. Technol. 162, 157–178 (2023)

    Article  Google Scholar 

  2. R. Khalilov, ABES, 8 (2023)

  3. S. Lee, M. Yusop, W. Ng, M. Ahmad, S. Tan, IJEST 20, 9111 (2023)

    CAS  Google Scholar 

  4. J. Shi, S. Chen, L. Wang, X. Zhang, J. Gao, L. Jiang, D. Tang, L. Zhang, A. Midgley, D. Kong, J. Biomed. Mater. Res. Part B Appl. Biomater. 107, 2040 (2019)

    Article  CAS  Google Scholar 

  5. D. Braghirolli, V. Helfer, P. Chagastelles, T. Dalberto, D. Gamba, P. Pranke, Biomed. Mater. 12, 025003 (2017)

    Article  PubMed  CAS  Google Scholar 

  6. S. Aslani, M. Kabiri, M. Kehtari, H. Hanaee-Ahvaz, J. Cell. Physiol. 234, 16080 (2019)

    Article  PubMed  CAS  Google Scholar 

  7. M. Khodadoust, D. Mohebbi-Kalhori, N. Jirofti, CVET 9, 73 (2018)

    Google Scholar 

  8. Y. Lei, M. Rémy, C. Labrugère, M.-C. Durrieu, J. Mater. Sci. Mater. Med. 23, 2761 (2012)

    Article  PubMed  CAS  Google Scholar 

  9. H. Savoji, A. Hadjizadeh, M. Maire, A. Ajji, M.R. Wertheimer, S. Lerouge, Macromol. Biosci. 14, 1084 (2014)

    Article  PubMed  CAS  Google Scholar 

  10. S. Xiao, W. Xu, H. Ma, Fibers Polym. 13, 618 (2012)

    Article  CAS  Google Scholar 

  11. A. Nasibova, Adv. Biol. Earth Sci 8, 140 (2023)

    Google Scholar 

  12. M. Fallah-Darrehchi, P. Zahedi, P. Harirchi, M. Abdouss, A.C.S. Appl, Polym. Mater. 5, 1076 (2023)

    CAS  Google Scholar 

  13. M. Rani, U. Shanker, Green Functionalized Nanomaterials for Environmental Applications (Elsevier, NY., 2022), p.21

    Google Scholar 

  14. S. Chen, W. Yang, J. Mater. Chem. C 5, 10682 (2017)

    Article  CAS  Google Scholar 

  15. M. Atari, A. Saroukhani, M. Manshaei, P. Bateni, A.Z. Kharazi, E. Vatankhah, S.H. Javanmard, Biomater. Sci. 11(20), 6871–6880 (2023)

    Article  PubMed  CAS  Google Scholar 

  16. M. Lakhdar, ABES, 5 (2020).

  17. D. Pezzoli, E. Cauli, P. Chevallier, S. Fare, D. Mantovani, J. Biomed. Mater. Res. A 105, 2405 (2017)

    Article  PubMed  CAS  Google Scholar 

  18. A. Aazmi, D. Zhang, C. Mazzaglia, M. Yu, Z. Wang, H. Yang, Y.Y.S. Huang, L. Ma, Bioact. Mater. 31, 475 (2024)

    PubMed  CAS  Google Scholar 

  19. S. Jafari, S.S. Hosseini Salekdeh, A. Solouk, M. Yousefzadeh, Polym. Adv. Technol. 31, 284 (2020)

    Article  CAS  Google Scholar 

  20. S. Aslani, M. Kabiri, S. HosseinZadeh, H. Hanaee-Ahvaz, E.S. Taherzadeh, M. Soleimani, Microvasc. Res. 131, 104027 (2020)

    Article  PubMed  CAS  Google Scholar 

  21. R. Sepehri, P. Zahedi, M. Kabiri, C. Nojavan, Fibers Polym. 23, 3012 (2022)

    Article  CAS  Google Scholar 

  22. M. Hadidi, C. Tan, E. Assadpour, M.S. Kharazmi, S.M. Jafari, JCR 355, 327 (2023)

    Article  CAS  Google Scholar 

  23. N. El Menyiy, A. El Allam, S. Aboulaghras, I. Jaouadi, S. Bakrim, N. El Omari, M.A. Shariati, A. Miftakhutdinov, P. Wilairatana, M.S. Mubarak, Biomed. Pharmacother. 151, 113158 (2022)

    Article  PubMed  Google Scholar 

  24. E.N. Zare, D. Khorsandi, A. Zarepour, H. Yilmaz, T. Agarwal, S. Hooshmand, R. Mohammadinejad, F. Ozdemir, O. Sahin, S. Adiguzel, Bioact. Mater. 31, 87 (2024)

    Google Scholar 

  25. R. Dhandapani, S. Thangavelu, L. Ragunathan, R. Paramasivam, P. Velmurugan, S. Muthupandian, Appl. Biochem. Biotechnol. 194, 4702 (2022)

    Article  PubMed  CAS  Google Scholar 

  26. D. Mandal, T. Sarkar, R. Chakraborty, Appl. Biochem. Biotechnol. 195, 1319 (2023)

    Article  PubMed  CAS  Google Scholar 

  27. F.S. Chashmi, M. Khakbiz, P. Zahedi, M. Kabiri, Fibers Polym. 23, 2103 (2022)

    Article  CAS  Google Scholar 

  28. P. Gupta, B.B. Mandal, Adv. Funct. Mater. 31, 2100027 (2021)

    Article  CAS  Google Scholar 

  29. M. Tudu, A. Samanta, Eur. Polym. J. 11, 2022 (1801)

    Google Scholar 

  30. E. Ahmadian, A. Eftekhari, D. Janas, P. Vahedi, Nanotheranostics 7, 61 (2023)

    Article  PubMed  PubMed Central  Google Scholar 

  31. R. Pathak, V.D. Punetha, S. Bhatt, M. Punetha, Eur. Polym. J. 196, 112257 (2023)

    Article  CAS  Google Scholar 

  32. E. Aram, S. Mehdipour-Ataei, Int. J. Polym. Mater. Polym. Biomater. 70, 1167 (2021)

    Article  CAS  Google Scholar 

  33. A. Ghasemi, R. Imani, M. Yousefzadeh, S. Bonakdar, A. Solouk, H. Fakhrzadeh, Macromol. Mater. Eng. 304, 1900187 (2019)

    Article  Google Scholar 

  34. U. D’Amora, S. Dacrory, M.S. Hasanin, A. Longo, A. Soriente, S. Kamel, M.G. Raucci, L. Ambrosio, S. Scialla, Int. J. Pharm. 15, 338 (2023)

    Google Scholar 

  35. S. Ahmed, S. Ikram, IJPSR 6, 14 (2015)

    Google Scholar 

  36. V. Biju, Chem. Soc. Rev. 43, 744 (2014)

    Article  PubMed  CAS  Google Scholar 

  37. W. Zhu, H. Huang, Y. Dong, C. Han, X. Sui, B. Jian, Biomater. Sci. 17, 4610 (2019)

    CAS  Google Scholar 

  38. A.M. Yusof, N.A. Buang, L.S. Yean, M.L. Ibrahim, in AIP Conf Proc, 390, Year of Converence

  39. A. Bharadwaz, A.C. Jayasuriya, Mater. Sci. Eng. C 110, 110698 (2020)

    Article  CAS  Google Scholar 

  40. M.C. Biswas, B. Jony, P.K. Nandy, R.A. Chowdhury, S. Halder, D. Kumar, S. Ramakrishna, M. Hassan, M.A. Ahsan, M.E. Hoque, J. Polym. Environ. 30, 51–74 (2021)

    Article  Google Scholar 

  41. C. Liu, J. Dai, X. Wang, X. Hu, Polym. 15, 3003 (2023)

    Article  CAS  Google Scholar 

  42. A. Kumar, K. Sharma, A.R. Dixit, Carbon Lett. 31, 149 (2021)

    Article  Google Scholar 

  43. E.D. Giol, S. Van Vlierberghe, R.E. Unger, D. Schaubroeck, H. Ottevaere, H. Thienpont, C.J. Kirkpatrick, P. Dubruel, Macromol. Biosci. 18, 1800125 (2018)

    Article  Google Scholar 

  44. Z. Li, G. Luo, F. Wei, Y. Huang, Compos. Sci. Technol. 66, 1022 (2006)

    Article  CAS  Google Scholar 

  45. E.J. Torres-Martínez, J.M. Cornejo Bravo, A. Serrano Medina, G.L. Pérez González, L.J. Villarreal Gómez, Curr. Drug Deliv. 15, 1360 (2018)

    Article  PubMed  PubMed Central  Google Scholar 

  46. Y. Zhai, Y. Dou, D. Zhao, P.F. Fulvio, R.T. Mayes, S. Dai, Adv. Mater. 23, 4828 (2011)

    Article  PubMed  CAS  Google Scholar 

  47. J. Qiu, J. Terrones, J.J. Vilatela, M.E. Vickers, J.A. Elliott, A.H. Windle, ACS Nano 7, 8412 (2013)

    Article  PubMed  CAS  Google Scholar 

  48. E. Ahmadi, P. Harirchi, P. Zahedi, B. Bakhshandeh, S. Zolfagharian, A. Khatibi, Fibers Polym. 24, 2293–2303 (2023)

    Article  CAS  Google Scholar 

  49. N.T.B. Linh, C.D. Abueva, B.-T. Lee, Biomed. Mater. 12, 015026 (2017)

    Article  PubMed  Google Scholar 

  50. S. Farris, L. Introzzi, P. Biagioni, T. Holz, A. Schiraldi, L. Piergiovanni, Langmuir 27, 7563 (2011)

    Article  PubMed  CAS  Google Scholar 

  51. G. Hurwitz, G.R. Guillen, E.M. Hoek, J. Membr. Sci. 349, 349 (2010)

    Article  CAS  Google Scholar 

  52. S. Mazinani, A. Ajji, C. Dubois, Polym. Eng. Sci. 50, 1956 (2010)

    Article  CAS  Google Scholar 

  53. L. Soletti, Y. Hong, J. Guan, J.J. Stankus, M.S. El-Kurdi, W.R. Wagner, D.A. Vorp, Acta Biomater. 6, 110 (2010)

    Article  PubMed  CAS  Google Scholar 

  54. B.W. Ahn, Y.S. Chi, T.J. Kang, J. Appl. Polym. Sci. 110, 4055 (2008)

    Article  CAS  Google Scholar 

  55. J. Cuppoletti, Nanocomposites and Polymers with Analytical Methods (BoD–Books on Demand, 2011)

    Book  Google Scholar 

  56. P. Nakielski, T. Kowalczyk, T.A. Kowalewski, in Proceeding of the COMSOL Conference, 23, Year of Converence

  57. H. Patil, R.V. Tiwari, M.A. Repka, AAPS PharmSciTech 17, 20 (2016)

    Article  PubMed  CAS  Google Scholar 

  58. S. Bayati, P. Harirchi, P. Zahedi, A. Bayandori Moghaddam, J. Biomater. Sci. Polym. Ed. 34, 1019 (2023)

    Article  PubMed  CAS  Google Scholar 

  59. H. Chen, Z. Liu, P. Cebe, Polym. J. 50, 872 (2009)

    Article  CAS  Google Scholar 

  60. M. Taufiq Musa, N. Shaari, S.K. Kamarudin, Int. J. Energy Res. 45, 1309 (2021)

    Article  CAS  Google Scholar 

  61. Y. Niimi, F. Ichinose, Y. Ishiguro, K. Terui, S. Uezono, S. Morita, S. Yamane, Anesth. Analg. 89, 573 (1999)

    Article  PubMed  CAS  Google Scholar 

  62. M. Zallaghi, H. Azizi, J. Compos. Mater., 00219983221121847 (2023)

  63. N. Martiniello, M. Barlow, W. Wittich, Sci. Stud. Read. 26, 267 (2022)

    Article  Google Scholar 

  64. C. Cheng, X. Peng, H. Qi, X. Wang, X. Yu, Y. Wang, X. Yu, Biomed. Mater. 16, 065009 (2021)

    Article  CAS  Google Scholar 

  65. Q. Ran, Y. Xiang, Y. Liu, L. Xiang, F. Li, X. Deng, Y. Xiao, L. Chen, L. Chen, Z. Li, Sci. Rep. 5, 16209 (2015)

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  66. X. Wu, Y. Li, F. Raza, X. Wang, S. Zhang, R. Rong, M. Qiu, J. Su, Pharmaceutics 13, 99 (2021)

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  67. C.Y. Teh, P.M. Budiman, K.P.Y. Shak, T.Y. Wu, Ind. Eng. Chem. Res. 55, 4363 (2016)

    Article  CAS  Google Scholar 

  68. F. Chen, X. Li, X. Mo, C. He, H. Wang, Y. Ikada, J. Biomater. Sci. Polym. Ed. 19, 677 (2008)

    Article  PubMed  CAS  Google Scholar 

  69. X. Li, L. Wang, Y. Fan, Q. Feng, F.-Z. Cui, J. Nanomater. 2012, 6 (2012)

    Google Scholar 

  70. M. Orecchioni, D. Bedognetti, F. Sgarrella, F.M. Marincola, A. Bianco, L.G. Delogu, J. Transl. Med. 12, 1 (2014)

    Article  Google Scholar 

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Acknowledgements

The authors would like to express their sincere gratitude to the Research Council of University of Tehran for the financial support in this work.

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Authors and Affiliations

  1. Nano-Biopolymers Research Laboratory, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, 11155-4563, Iran

    Chakavak Nojavan, Romina Sepehri, Parmida Harirchi, Payam Zahedi & Sohrab Ali Ghorbanian

  2. Department of Biotechnology, College of Science, University of Tehran, Tehran, 14155-6455, Iran

    Mahboubeh Kabiri & Zahra Kharat

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  1. Chakavak Nojavan
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  2. Romina Sepehri
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Correspondence to Payam Zahedi or Mahboubeh Kabiri.

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Nojavan, C., Sepehri, R., Harirchi, P. et al. Potential Use of Electrospun Poly(ethylene terephthalate)/Carbon Nanotubes Containing Aspirin in Vascular Tissue Engineering Application. Fibers Polym 25, 71–81 (2024). https://doi.org/10.1007/s12221-023-00429-9

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