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Fabrication of Gehlenite Nanopowder Containing Electrospun Nanofibers for Bone Tissue Engineering

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Abstract

Bioactive Polycaprolactone/Collagen nanofibers containing gehlenite Nano-powder were fabricated using electrospinning for bone tissue engineering. The physicochemical properties of scaffolds measured using scanning electron microscopy, tensile test, FTIR spectroscopy, and water contact angle measurement test. A slight enhancement (∼20 nm) in fibers diameter was observed by adding gehlenite nanoparticles to the scaffolds, but the fiber diameter distributions for both scaffolds were within the normal range of extracellular matrix (50–500 nm). In vitro experiments demonstrated well attachment and higher proliferation of MG-63 cells on gehlenite nanoparticles containing scaffolds. Besides, the stimulatory cell differentiation effects of Polycaprolactone/Collagen/gehlenite scaffolds were demonstrated by Alizarin red staining. This study represents for advanced of the natural and synthetic polymers for bone tissue engineering.

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Authors and Affiliations

  1. Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, 761, Iran

    Mohsen Doostmohammadi & Shahram Amini

  2. Department of Biotechnology, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan, 83, Iran

    Mohammad Mehrasa

  3. Institute for Frontier Materials, Deakin University, Geelong, Victoria, 3217, Australia

    Zahra Komeily-Nia & Bijan Nasri-Nasrabadi

  4. School of Engineering, Deakin University, Geelong, Victoria, 3217, Australia

    Pejman Heidarian

  5. Department of Biomaterials, Tissue Engineering and Nanotechnology, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, 81745-33871, Iran

    Ashkan Bigham

  6. Biosensor Research Center, Isfahan University of Medical Sciences, Isfahan, 81745-33871, Iran

    Mohammad Rafienia

Authors
  1. Mohsen Doostmohammadi
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  2. Mohammad Mehrasa
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  3. Ashkan Bigham
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  4. Mohammad Rafienia
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  5. Shahram Amini
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  6. Zahra Komeily-Nia
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  7. Pejman Heidarian
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  8. Bijan Nasri-Nasrabadi
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Correspondence to Bijan Nasri-Nasrabadi.

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Doostmohammadi, M., Mehrasa, M., Bigham, A. et al. Fabrication of Gehlenite Nanopowder Containing Electrospun Nanofibers for Bone Tissue Engineering. Fibers Polym 22, 3281–3288 (2021). https://doi.org/10.1007/s12221-021-0168-x

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  • DOI: https://doi.org/10.1007/s12221-021-0168-x

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