Abstract
Electrospun blends of biphasic calcium phosphate (BCP) loaded polyvinyl alcohol (PVA)-gelatin (GE) were created with the aim of fabricating biodegradable scaffolds for bone tissue engineering. The process parameters including the electrical field and tip-to-collector distance (TCD) were investigated. The morphology of these hybrid scaffolds were characterized by scanning electron microscope (SEM). X-ray diffraction (XRD) was used to determine the crystallinity of the membrane. Adhesion of osteoblastic cells (MG-63) onto the BCP loaded PVA/GE composite nano-fiber mat was performed to assess potential of the product as a bone scaffold. This result suggests that the BCP loaded PVA/GE composite nano-fiber mat has a high potential for use in the field of bone regeneration and tissue engineering.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Patrick, C.W., Mikos, A.G., McIntire, L.V.: Frontiers in Tissue Engineering. Elsevier (1998)
Greiner, A., Wendorff, J.H.: Angew. Chem. Int. Ed. 46(30), 5670–5703 (2007)
Zhang, Y., Ouyang, H., Lim, C.T., Ramakrishna, S., Huang, Z.M.: J. Biomed. Mater. Res. Part B: Appl. Biomater. 72(1), 156–165 (2005)
Rujitanaroj, P.-O., Pimpha, N., Supaphol, P.: Polymer 49(21), 4723–4732 (2008)
Linh, B., Thuy, N., Lee, K.H., Lee, B.T.: J. Biomed. Mater. Res. Part A 101(8), 2412–2423 (2013)
Zhang, H., Xia, J., Pang, X., Zhao, M., Wang, B., Yang, L., Wan, H., Wu, J., Fu, S.: Mater. Sci. Eng. C 73, 537–543 (2017)
Lutolf, M., Hubbell, J.: Nat. Biotechnol. 23(1), 47 (2005)
Linh, N.T.B., Lee, B.-T.: J. Biomater. Appl. 27(3), 255–266 (2012)
Yang, D., Li, Y., Nie, J.: Carbohyd. Polym. 69(3), 538–543 (2007)
Jayaraman, P., Gandhimathi, C., Venugopal, J.R., Becker, D.L., Ramakrishna, S., Srinivasan, D.K.: Adv. Drug Deliv. Rev. 94, 77–95 (2015)
Tateishi, T., Chen, G., Ushida, T.: J. Artif. Organs 5(2), 77–83 (2002)
Liu, X., Ma, P.X.: Ann. Biomed. Eng. 32(3), 477–486 (2004)
Linh, N.T.B., Min, Y.K., Song, H.Y., Lee, B.T.: J. Biomed. Mater. Res. Part B: Appl. Biomater. 95(1), 184–191 (2010)
Teixeira, A.I., Nealey, P.F., Murphy, C.J.: J. Biomed. Mater. Res. Part A 71(3), 369–376 (2004)
Laurencin, C.T., Ambrosio, A., Borden, M., Cooper Jr., J.: Annu. Rev. Biomed. Eng. 1(1), 19–46 (1999)
Conflicts of Interest Statement
The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Singapore Pte Ltd.
About this paper
Cite this paper
Nguyen, L.T.B., Nguyen, TH., Huynh, CK., Lee, BT., Ye, H. (2020). Composite Nano-fiber Mats Consisting of Biphasic Calcium Phosphate Loaded Polyvinyl Alcohol—Gelatin for Bone Tissue Engineering. In: Van Toi , V., Le, T., Ngo, H., Nguyen, TH. (eds) 7th International Conference on the Development of Biomedical Engineering in Vietnam (BME7). BME 2018. IFMBE Proceedings, vol 69. Springer, Singapore. https://doi.org/10.1007/978-981-13-5859-3_53
Download citation
DOI: https://doi.org/10.1007/978-981-13-5859-3_53
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-13-5858-6
Online ISBN: 978-981-13-5859-3
eBook Packages: EngineeringEngineering (R0)