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Electrospun in-situ hybrid polyurethane/nano-TiO2 as wound dressings

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Abstract

By combining the organic-inorganic hybridization, wet phase inversion, and electrospinning, novel electrospun polyurethane (PU) membranes with in-situ generated nano-TiO2 were prepared, which satisfied the requirements of an ideal wound dressing. The morphology of the PU-TiO2 mats and the cross sectional morphologies of the membranes were characterized by a scanning electron microscopy (SEM). The average diameter of the individual fibers obtained from the solutions was 341±12 nm. SEM micrographs with higher magnification further showed that the in-situ generated TiO2 particles were well-separated and dispersed homogeneously in the membranes. The average sizes of TiO2 particles were increased from 31 to 57 nm, with the increase of nano-TiO2 concentration. The water vapor transmission rates (WVTRs) of the membranes were in the range of 373.55–3121.86 g/m2·d and decreased gradually with the increase of nano-TiO2 concentration. The water absorption of various PU membranes was in the range of 210.90–397.98 % which was enough to prevent wound beds from exudate accumulation. Shake flask testing indicated that the PU membrane exhibited antibacterial efficiency against Pseudomonas aeruginosa (Ps. aeruginosa) and Staphylococcus aureus (S. aureus) due to in-situ generated of nano-TiO2. These electrospun nanofibrous membranes also had no toxic effect and showed good and immediate adherence to L929 cells.

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References

  1. L. S. Wang, P. Y. Chow, D. C. W. Tan, W. D. Zhang, and Y. Y. Yang, Adv. Mater., 16, 1790 (2004).

    Article  CAS  Google Scholar 

  2. L. G. Ovington, Clin. Dermatol., 25, 33 (2007).

    Article  Google Scholar 

  3. G. M. Menaker, Semin. Cutan. Med. Surg., 21, 171 (2002).

    Article  Google Scholar 

  4. M. U. Ozkaynak, A. O. Cigdem, T. E. S. Birgul, and G. F. Seniha, Macromol. Symp., 228, 177 (2005).

    Article  CAS  Google Scholar 

  5. Y. S. Cho, J. W. Lee, J. S. Lee, J. H. Lee, T. R. Yoon, and Y. Kuroyanagi, J. Mater. Sci. Mater. M., 13, 861 (2002).

    Article  CAS  Google Scholar 

  6. M. S. Khil, D. I. Cha, H. Y. Kim, I. S. Kim, and N. Bhattarai, J. Biomed. Mater. Res. B., 67B, 675 (2003).

    Article  CAS  Google Scholar 

  7. H. J. Yoo and H. D. Kim, J. Biomed. Mater. Res. B., 85B, 326 (2008).

    Article  CAS  Google Scholar 

  8. Y. Chen, L. D. Yan, T. Yuan, Q. Y. Zhang, and H. J. Fan, J. Appl. Polym. Sci., DOI:10.1002/APP.32813 (2010).

  9. M. Song, R. Y. Zhang, and X. M. Wang, Mater. Lett., 60, 2143 (2006).

    Article  CAS  Google Scholar 

  10. G. L. Wang, J. Wang, and R. W. Murray, Anal. Chem., 74, 4320 (2002).

    Article  CAS  Google Scholar 

  11. C. H. Fan, K. W. Plaxco, and A. J. Heeger, J. Am. Chem. Soc., 124, 5642 (2002).

    Article  CAS  Google Scholar 

  12. C. S. Yang, C. H. Chang, P. J. Tsai, W. Y. Chen, F. G. Tseng, and L. W. Lo, Anal. Chem., 76, 4465 (2004).

    Article  CAS  Google Scholar 

  13. R. Dastjerdi and M. Montazer, Colloid. Surface. B., 79, 5 (2010).

    Article  CAS  Google Scholar 

  14. Y. Z. Zhang, J. Venugopal, Z. M. Huang, C. T. Lim, and S. Ramakrishna, Polymer, 47, 2911 (2006).

    Article  CAS  Google Scholar 

  15. R. K. Mohammad and H. Y. Jeong, Soft. Mater., 8, 197 (2010).

    Article  Google Scholar 

  16. R. Clarisse, S. Vitor, L. G. R. José, and L. M. Senentxu, Soft. Mater., 8, 274 (2010).

    Article  Google Scholar 

  17. A. F. Lotus, R. K. Feaver, L. A. Britton, E. T. Bender, D. A. Perhay, N. Stojilovic, R. D. Ramsier, and G. G. Chase, Mat. Sci. Eng. B, Solid, 167, 55 (2010).

    Article  CAS  Google Scholar 

  18. C. J. Luo, M. Nangrejo, and M. Edirisinghe, Polymer, 51, 1654 (2010).

    Article  CAS  Google Scholar 

  19. E. A. T. Vargas, N. C. V. Baracho, J. D. Brito, and A. A. A. Queiroz, Acta. Biomater., 6, 1069 (2010).

    Article  CAS  Google Scholar 

  20. Y. S. Zhou, D. Z. Yang, X. M. Chen, Q. Xu, F. M. Lu, and J. Nie, Bimacromolecules, 9, 349 (2008).

    Article  CAS  Google Scholar 

  21. J. P. Chen, G. Y. Chang, and J. K. Chen, Colloid. Surface. A, 313–314, 183 (2008).

    Article  Google Scholar 

  22. S. A. Sell, M. J. McClure, C. P. Barnes, and G. L. Bowlin, Biomed. Mater., 1, 72 (2006).

    Article  CAS  Google Scholar 

  23. S. J. Lee, J. J. Yoo, G. J. Lim, A. Atala, and J. Stitze, J. Biomed. Mater. Res. A., 83A, 999 (2007).

    Article  CAS  Google Scholar 

  24. T. J. Still and R. H. A. Von, Biomaterials, 29, 1989 (2008).

    Article  Google Scholar 

  25. Annual Book of ASTM Standards, Vol. 4.06. Philadelphia: ASTM, 2000.

  26. M. I. Lesseva and O. G. Hadjiiski, Burns., 22, 279 (1996).

    Article  CAS  Google Scholar 

  27. B. F. Ye, “Practical Wound Care”, 1st ed., Science and Technology Literature Press: Beijing, 1999.

    Google Scholar 

  28. L. O. Lamke, G. E. Nilsson, and H. L. Reithner, Burns., 3, 159 (1977).

    Article  Google Scholar 

  29. D. Queen, J. D. S. Gaylor, J. H. Evans, and J. M. Courtney, Biomaterials, 8, 367 (1987).

    Article  CAS  Google Scholar 

  30. T. S. Yu, J. P. Lin, J. F. Xu, T. Chen, and S. L. Lin, Polymer, 46, 5695 (2005).

    Article  CAS  Google Scholar 

  31. Z. Huang, P. C. Maness, D. M. Blake, E. J. Wolfrum, S. L. Smolinski, and W. A. Jacoby, J. Photoch. Photobio. A, 130, 163 (2000).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. School of Chemical Engineering, Sichuan University, Chengdu, 610065, P.R. China

    Lidan Yan, Shaoxiong Si & Qiyi Zhang

  2. National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University, Chengdu, 610065, P.R. China

    Yi Chen & Haojun Fan

  3. National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, P.R. China

    Tun Yuan

  4. Textile Institute, Sichuan University, Chengdu, 610065, P.R. China

    Yongyi Yao

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  1. Lidan Yan
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  2. Shaoxiong Si
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  3. Yi Chen
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  4. Tun Yuan
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  5. Haojun Fan
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  6. Yongyi Yao
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  7. Qiyi Zhang
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Correspondence to Qiyi Zhang.

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Yan, L., Si, S., Chen, Y. et al. Electrospun in-situ hybrid polyurethane/nano-TiO2 as wound dressings. Fibers Polym 12, 207–213 (2011). https://doi.org/10.1007/s12221-011-0207-0

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  • DOI: https://doi.org/10.1007/s12221-011-0207-0

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