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XPC intron11 C/A polymorphism as a risk factor for prostate cancer

  • Regular Article
  • Published:
Environmental Health and Preventive Medicine Aims and scope

Abstract

Objectives

DNA repair genes play an important role in protection against environmental and endogenous DNA damage, and constitute the first line of defense against cancer. Xeroderma pigmentosum complementation group C (XPC) is involved in the damage recognition step during nucleotide excision repair. The relationship between XPC intron11 C/A polymorphism and cancer risk has not been widely studied. Hence, this study evaluated the relationship between the XPC intron11 C/A polymorphism and prostate cancer risk.

Materials and methods

This hospital-based cohort consisted of 152 patients with prostate cancer and 142 male controls. The XPC intron11 C/A genotype was determined using the PCR–RFLP method. Medical, occupational, and cigarette-smoking history was obtained from each participant using questionnaires.

Results

Logistic regression analysis revealed that compared to controls, the frequencies of the A/A and C/A genotypes were significantly higher than those of the C/C genotype in cancer patients (OR = 2.03, 95 % confidence interval (CI) 1.03–3.98 and OR = 1.91, 95 % CI 1.13–3.24, respectively). We also found that the frequency of the A/A genotype was significantly higher in cancer cases than in controls among non-smokers (OR = 7.7, 95 % CI 1.38–42.88, compared to the C/C genotype).

Conclusion

We found that the XPC intron11 C/A polymorphism was associated with an increased risk of prostate cancer. Among non-smokers, the A/A genotype was significantly more prevalent in prostate cancer patients than in controls.

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Acknowledgments

This work was supported by the Faculty of Medicine, University of Miyazaki and the University of Occupational and Environmental Health. We are especially grateful to the staff of these facilities. [23].

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Authors and Affiliations

  1. Department of Public Health, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan

    Yoshihiro Yoshino, Shouhei Takeuchi & Yoshiki Kuroda

  2. Department of Public Health, Faculty of Life Science, University of Kumamoto, 1-1-1 Honjyoh, Chuou-ku, Kumamoto, 860-8556, Japan

    Takahiko Katoh

Authors
  1. Yoshihiro Yoshino
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  2. Shouhei Takeuchi
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  3. Takahiko Katoh
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Correspondence to Yoshiki Kuroda.

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Yoshino, Y., Takeuchi, S., Katoh, T. et al. XPC intron11 C/A polymorphism as a risk factor for prostate cancer. Environ Health Prev Med 21, 100–104 (2016). https://doi.org/10.1007/s12199-015-0505-z

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  • DOI: https://doi.org/10.1007/s12199-015-0505-z

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