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Sequential dual-energy subtraction technique with a dynamic flat-panel detector (FPD): primary study for image-guided radiation therapy (IGRT)

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Abstract

A sequential dual-energy subtraction technique for image-guided radiation therapy (IGRT) was developed. Here, we report on a computerized method for creating sequential soft-tissue images and the accuracy of tracking targets on the images obtained, in comparison to conventional fluoroscopic images. Two sets of sequential chest images during respiration of a normal subject were obtained with X-rays of different energy separately with a flat-panel detector (FPD). Sequential soft-tissue images were created from the two sets of sequential images consisting of real-time images and reference template images, respectively. The creation of sequential soft-tissue images consisted of three steps: one-to-one image correspondence of the two sequential images, image registration, and image subtraction in each frame. Motion tracking of lung vessels was then performed by the template-matching technique. For evaluation of the accuracy of motion tracking on the sequential soft-tissue images, the results were compared with those on the original sequential images. Sequential soft-tissue images provided more accurate tracking than the original images (P < 0.01). There was no significant error throughout all frames in the soft-tissue images, whereas the rib shadow introduced a tracking error in the original images. The maximum errors were 4.1 ± 0.3 mm in the sequential soft-tissue images and 28.1 ± 20.0 mm in the original images. In conclusion, sequential soft-tissue images were helpful for tracking of a target affected by respiratory motion. Dual-energy subtraction has the potential to improve the accuracy of IGRT without implanted markers.

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Acknowledgments

This work was supported in part by a Grant-in-Aid for Scientific Research from the Japanese Ministry of Education, Culture, Sports, Science, and Technology, and the Konica Minolta Imaging Science Foundation. The authors thank the technologists of the Department of Radiology, Kanazawa University Hospital, who assisted with data acquisition, and Dr Shinichiro Mori at the National Institute of Radiological Sciences for valuable discussions regarding technical and clinical feasibility. The authors thank the editors and reviewers who spent time giving us informative advice to improve our manuscript.

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Authors and Affiliations

  1. Division of Health Sciences, Radiology, Graduate School of Medical Science, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, 920-0942, Japan

    Rie Tanaka & Shigeru Sanada

  2. Department of Radiology, Kanazawa University Hospital, 13-1 Takaramachi, Kanazawa, 920-8641, Japan

    Takeshi Matsui & Norio Hayashi

  3. Department of Radiology, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920-8641, Japan

    Osamu Matsui

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  1. Rie Tanaka
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  2. Shigeru Sanada
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  3. Takeshi Matsui
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  4. Norio Hayashi
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  5. Osamu Matsui
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Correspondence to Rie Tanaka.

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Tanaka, R., Sanada, S., Matsui, T. et al. Sequential dual-energy subtraction technique with a dynamic flat-panel detector (FPD): primary study for image-guided radiation therapy (IGRT). Radiol Phys Technol 1, 144–150 (2008). https://doi.org/10.1007/s12194-008-0021-6

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  • DOI: https://doi.org/10.1007/s12194-008-0021-6

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