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The atheroprotective properties of Hsp70: a role for Hsp70-endothelial interactions?

  • Perspective and Reflection Article
  • Published:
Cell Stress and Chaperones Aims and scope

Abstract

Although heat shock (stress) proteins are typically regarded as being exclusively intracellular molecules, it is now apparent that they can be released from cells in the absence of cellular necrosis. We and others have reported the presence of Hsp60 (HSPD1) and Hsp70 (HSPA1A) in the circulation of normal individuals and our finding that increases in carotid intima-media thicknesses (a measure of atherosclerosis) in subjects with hypertension at a 4-year follow-up are less prevalent in those having high serum Hsp70 (HSPA1A) levels at baseline suggests that circulating Hsp70 (HSPA1A) has atheroprotective effects. Given that circulating Hsp70 (HSPA1A) levels can be in the range which has been shown to elicit a number of biological effects in vitro, and our preliminary findings that Hsp70 (HSPA1A) binds to and is internalised by human endothelial cell populations, we speculate on the mechanisms that might be involved in the apparent atheroprotective properties of this protein.

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Acknowledgements

We thank Dr. Mathias Gehrmann (Technische Universität München) for performing the fluorescent microscopy. We also thank Professor Nicola J. Brown (University of Sheffield) for providing primary human dermal microvascular endothelial cells.

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Authors and Affiliations

  1. Immunobiology Research Unit, K Floor, School of Medicine and Biomedical Sciences, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, UK

    A. Graham Pockley

  2. Department of Radiation Oncology, Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, MA, USA

    Stuart K. Calderwood

  3. Department of Radiotherapy and Radio-oncology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany

    Gabriele Multhoff

  4. Helmholtz Centre Munich, German Research Centre for Environmental Health (GmbH), Institute of Pathology, Clinical Cooperation Group “Innate Immunity in Tumour Biology”, Munich, Germany

    Gabriele Multhoff

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  1. A. Graham Pockley
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  2. Stuart K. Calderwood
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  3. Gabriele Multhoff
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Correspondence to A. Graham Pockley.

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Pockley, A.G., Calderwood, S.K. & Multhoff, G. The atheroprotective properties of Hsp70: a role for Hsp70-endothelial interactions?. Cell Stress and Chaperones 14, 545–553 (2009). https://doi.org/10.1007/s12192-009-0113-1

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  • DOI: https://doi.org/10.1007/s12192-009-0113-1

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