Skip to main content
SpringerLink
Log in

Spinal epidural granulocytic sarcoma in non-leukemic patient

  • Case Report
  • Published:
International Journal of Hematology Aims and scope Submit manuscript

Abstract

A previously healthy 24-year-old male presented with a 3-month history of progressive backache and weakness in both legs. Magnetic resonance imaging of the spine showed a large soft tissue mass infiltrating paraspinal musculature of lumbosacral area, sacral laminas, last lumbar and all sacral vertebra, protruding into the spinal canal, and with propagation into pelvis. Baseline laboratory data were normal. Decompressive laminectomy and tumor removal were performed resulting in neurological improvement. Histological examination identified granulocytic sarcoma (GS). Bone marrow biopsy showed normal findings. The patient underwent adjuvant chemotherapy and radiotherapy, resulting in the elimination of residual lesion, followed by autologous transplant. Immediate diagnosis and adequate systematic treatment are essential to achieve optimal results in patients with isolated GS. The patient is alive and free of the disease 14 months from the diagnosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Balleari E, Panarello S, Capello E, Grosso M, Passalia C, Pitto P, et al. Granulocytic sarcoma: an unusual cause of spinal cord compression. Int J Clin Oncol. 2007;12:234–7. doi:10.1007/s10147-006-0645-7.

    Article  PubMed  Google Scholar 

  2. Neiman RS, Barcos M, Berard C, et al. Granulocytic sarcoma: a clinicopathologic study of 61 biopsy cases. Cancer. 1981;48:1426–37. doi:10.1002/1097-0142(19810915)48:6<1426::AID-CNCR2820480626>3.0.CO;2-G.

    Article  CAS  PubMed  Google Scholar 

  3. Landis MD, Aboulafia MD. Granulocytic sarcoma: an unusual complication of aleukemic myeloid leukemia causing spinal cord compression. A case report and literature review. Leuk Lymphoma. 2003;44:1753–60. doi:10.1080/1042819031000104051.

    Article  PubMed  Google Scholar 

  4. Scheinberg DA, Maslak P, Weiss M. Leukemias. In: Devita VT, Hellman S, Rosenberg SA, editors. Cancer: principles and practices of oncology, chap. 46.2. Philadelphia: Lippincott Williams and Wilkins; 2001. p. 2427–9.

  5. Chevallier P, Mohty MB, et al. Allogeneic hematopoietic stem-cell transplantation for myeloid sarcoma: a retrospective study from the SFGM-TC. J Clin Oncol. 2008;26(25):1–4.

    Google Scholar 

  6. Kozelj M, Zorman D, Mrevlje B, et al. Cardiac granulocytic sarcoma diagnosed by intracardiac echocardiography-guided biopsy. Int J Hematol. 2008;88(1):101–3. doi:10.1007/s12185-008-0104-5.

    Article  PubMed  Google Scholar 

  7. Kitagawa Y, Sameshima Y, Shiozaki H, et al. Isolated granulocytic sarcoma of the small intestine successfully treated with chemotherapy and bone marrow transplantation. Int J Hematol. 2008;87:410–3. doi:10.1007/s12185-008-0067-6.

    Article  PubMed  Google Scholar 

  8. Antic D, Vuckovic M, Elezovic I. Right atrial myeloid sarcoma causing superior vena cava syndrome. Br J Haematol. 2008;141(2):134. doi:10.1111/j.1365-2141.2008.07032.x.

    Article  PubMed  Google Scholar 

  9. Brunning RD, Matutes E, Flandrin G, et al. Acute myeloid leukemia not otherwise categorized. In: Jaffe ES, Harris NL, Stein H, Vardiman JW, editors. Pathology and genetics of tumours of haepatopoetic and lymphoid tissues. Lyon: IARC; 2001. p. 104–5.

  10. Byrd JC, Edenfiled WJ, Shields DJ, Dawson NA. Extramedullary myeloid cell tumors in acute nonlymphocytic leukemia: a clinical review. J Clin Oncol. 1995;13:1800–16.

    Article  CAS  PubMed  Google Scholar 

  11. Yamauchi K, Yasuda M. Comparison in treatments of nonleukemic granulocytic sarcoma. Cancer. 2002;94(6):1739–46. doi:10.1002/cncr.10399.

    Article  PubMed  Google Scholar 

  12. Tsimberidou AM, Kantarjian HM, Estey E, et al. Outcome in patients with nonleukemic granulocytic sarcoma treated with chemotherapy with or without radiotherapy. Leukemia. 2003;17:1100–3. doi:10.1038/sj.leu.2402958.

    Article  PubMed  Google Scholar 

  13. Pileri SA, Ascani S, Cox MC, et al. Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients. Leukemia. 2007;21:340–50. doi:10.1038/sj.leu.2404491.

    Article  CAS  PubMed  Google Scholar 

  14. Inoue T, Tkahashi T, Shimizu H, et al. Spinal granulocytic sarcoma manifesting as radiculopathy in a nonleukemic patient. Neurol Med Chir (Tokyo). 2008;48:131–6. doi:10.2176/nmc.48.131.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Hematology, Clinical Center of Serbia, Koste Todorovica 2, 11000, Belgrade, Serbia

    Darko Antic, Ivo Elezovic, Dana Grujicic, Mirjana Gotic, Jelena Bila, Maja Perunicic & Ljubomir Jakovic

  2. Leukemia Department, MD Anderson Cancer Center, Houston, TX, USA

    Srdan Verstovsek

Authors
  1. Darko Antic
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Srdan Verstovsek
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ivo Elezovic
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Dana Grujicic
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Mirjana Gotic
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jelena Bila
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Maja Perunicic
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Ljubomir Jakovic
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Darko Antic.

About this article

Cite this article

Antic, D., Verstovsek, S., Elezovic, I. et al. Spinal epidural granulocytic sarcoma in non-leukemic patient. Int J Hematol 89, 95–97 (2009). https://doi.org/10.1007/s12185-008-0227-8

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12185-008-0227-8

Keywords

Search

Navigation