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Cardiac granulocytic sarcoma diagnosed by intracardiac echocardiography-guided biopsy

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Abstract

A 52-year-old man presented with clinical and echocardiographic signs of cardiac tamponade. A transthoracic echocardiogram revealed a large right atrial mass that obstructed the superior vena cava flow. Cardiac magnetic resonance imaging and computed tomography demonstrated extracardiac tumour invasion of the free atrial wall extending to the right pulmonary hilus. Intracardiac echocardiography-guided biopsy of the tumour revealed the tissue diagnosis-granulocytic sarcoma of the heart. The patient was effectively treated with radiotherapy, chemotherapy and allogeneic haematopoietic stem cell transplantation. He has remained free of the disease for 12 months after treatment.

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References

  1. Menasce LP, Banerjee SS, Beckett E, Harris M. Extra-medullary myeloid tumour (granulocytic sarcoma) is often misdiagnosed: a study of 26 cases. Histopathology. 1999;34:391−8.

    Article  CAS  PubMed  Google Scholar 

  2. Mathiot C, Le Carpentier Y, Sol C, Varet B, Levy JP. Multifocal chloroma (granulocytic sarcoma), without marrow involvement. One case. Nouv Presse Med. 1978;28:2461−3.

    Google Scholar 

  3. Foucar K, Foucar E, Willman C, Horvath A, Gerety RL. Nonleukemic granulocytic sarcoma of the heart: a report of a fatal case. Am J Hematol. 1987;25:325−32.

    Article  CAS  PubMed  Google Scholar 

  4. Ichikawa K, Ishizuka N, Shimamura K, et al. Mitral valve stenosis due to primary cardiac granulocytic sarcoma relapsing 8 years after complete remission: a case report. J Cardiol. 2001;4:219−24.

    Google Scholar 

  5. Gabert J, Beillard E, van der Velden VH, Bi W, Grimwade D, Pallisgaard N, et al. Standardization and quality control studies of ”real-time” quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia-a Europe Against Cancer program. Review. Leukemia. 2003;17(12):2318−57.

    Article  CAS  PubMed  Google Scholar 

  6. Nakao M, Yokota S, Iwai T, Kaneko H, Horiike S, Kashima K, et al. Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. Leukemia. 1996;10:1911−8.

    CAS  PubMed  Google Scholar 

  7. Pai VB, Nahata MC. Cardiotoxicity of chemotherapeutic agents. Drug Saf. 2000;22(4):263−302.

    Article  CAS  PubMed  Google Scholar 

  8. Schwarz J, Trnkova Z, Bedrlikova R, Jirasek A, Zakova D, Trneny M, et al. Aleukemic granulocytic sarcoma with AML1/ETO fusion gene expression and clonal T cell populations. Leuk Res. 2001;25(12):1137−42.

    Article  CAS  PubMed  Google Scholar 

  9. Kara IO, Sahin B, Paydas S, Kara B. Granulocytic sarcoma of the heart: extramedullary relapse of acute myeloblastic leukemia after allogeneic stem cell transplantation successfully treated by chemotherapy alone. Leuk Lymphoma. 2005;46(7):1081−4.

    Article  PubMed  Google Scholar 

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Correspondence to Mirta Koželj.

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Koželj, M., Zorman, D., Mrevlje, B. et al. Cardiac granulocytic sarcoma diagnosed by intracardiac echocardiography-guided biopsy. Int J Hematol 88, 101–103 (2008). https://doi.org/10.1007/s12185-008-0104-5

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  • DOI: https://doi.org/10.1007/s12185-008-0104-5

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