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Synthesis of a series of novel 2,5-disubstituted-1,3,4-oxadiazole derivatives as potential antioxidant and antibacterial agents

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Journal of Chemical Biology

Abstract

A series of novel 2,5-disubstituted-1,3,4-oxadiazole derivatives were synthesized and screened for their antimicrobial and antioxidant activities. The assay indicated that compounds 3c, 3d, and 3i exhibited comparable antibacterial and antioxidant activity with first-line drugs. The structure activity relationship and molecular docking study of the synthesized compounds are also reported.

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Acknowledgments

The authors are thankful to the Department of Industrial Chemistry, Kuvempu University, Shankaraghatta, for providing the laboratory facilities to carry out the research work.

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Authors and Affiliations

  1. Department of P.G. Studies and Research in Industrial Chemistry, Jnana Sahyadri, Kuvempu University, Shankaraghatta, 577451, Shivamogga, Karnataka, India

    M. Aruna Sindhe, Yadav D. Bodke, R. Kenchappa & A. Chandrashekar

  2. Department of P.G. Studies and Research in Biotechnology, Jnana Sahyadri, Kuvempu University, Shankaraghatta, 577451, Shivamogga, Karnataka, India

    Sandeep Telkar

Authors
  1. M. Aruna Sindhe
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  2. Yadav D. Bodke
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  3. R. Kenchappa
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  4. Sandeep Telkar
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  5. A. Chandrashekar
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Correspondence to Yadav D. Bodke.

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Sindhe, M.A., Bodke, Y.D., Kenchappa, R. et al. Synthesis of a series of novel 2,5-disubstituted-1,3,4-oxadiazole derivatives as potential antioxidant and antibacterial agents. J Chem Biol 9, 79–90 (2016). https://doi.org/10.1007/s12154-016-0153-9

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  • DOI: https://doi.org/10.1007/s12154-016-0153-9

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