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18F-FDG uptake in primary lung cancer as a predictor of intratumoral vessel invasion

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Abstract

Objective

This study investigated how fluorodeoxyglucose (FDG) uptake on PET in the primary tumor may predict intratumoral vessel invasion (IVI) in it.

Methods

A total of 512 patients with lung neoplasms determined by a surgical procedure and histopathological diagnosis had undergone FDG-PET scanning.

Results

Among the 440 cases confirmed to be malignant, the maximum standardized uptake value (SUVmax) was significantly lower in IVI-negative cases than IVI-positive cases (P < 0.001). In the substudy on adenocarcinoma (AC), SUVmax was significantly lower in IVI-negative cases too (P < 0.001), but SUVmax in squamous cell carcinoma was without significant difference. In addition, IVI was associated with a significantly higher probability of lymph node metastasis (P < 0.001).

Conclusions

This study indicates that a malignant lung tumor with higher SUVmax has a significantly higher probability of IVI and lymph node metastasis, particularly if the malignancy is an AC.

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Acknowledgment

The authors thank Masaaki Sato MD, PhD for helpful information about pathological issues and photograph of IVI lesion.

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Authors and Affiliations

  1. Department of Radiology, Sapporo Minamisanjo Hospital, 4-2 Minami3 Nishi6, Sapporo, Hokkaido, 060-0063, Japan

    Tetsuya Ishibashi

  2. Department of Surgery, Sapporo Minamisanjo Hospital, Sapporo, Hokkaido, Japan

    Mitsuhito Kaji, Tatsuya Kato, Keidai Ishikawa & Masatoshi Kadoya

  3. Department of Nuclear Medicine, Hokkaido University, Sapporo, Hokkaido, Japan

    Nagara Tamaki

Authors
  1. Tetsuya Ishibashi
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  2. Mitsuhito Kaji
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  3. Tatsuya Kato
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  4. Keidai Ishikawa
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  5. Masatoshi Kadoya
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  6. Nagara Tamaki
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Correspondence to Tetsuya Ishibashi.

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Ishibashi, T., Kaji, M., Kato, T. et al. 18F-FDG uptake in primary lung cancer as a predictor of intratumoral vessel invasion. Ann Nucl Med 25, 547–553 (2011). https://doi.org/10.1007/s12149-011-0502-2

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  • DOI: https://doi.org/10.1007/s12149-011-0502-2

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