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Relationship between maximum standardized uptake value (SUVmax) of lung cancer and lymph node metastasis on FDG-PET

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Abstract

Purpose

To evaluate the relationship between SUVmax of primary lung cancers on FDG-PET and lymph node metastasis.

Method and materials

The subjects were a total of consecutive 66 patients with lung cancer who were examined by FDG-PET and subsequently underwent surgery between October 2004 and January 2008. There were 41 males and 25 females, ranging in age from 45 to 83 years with an average of 68 years. The pathological subtypes of the lung cancers consisted of 49 adenocarcinomas, 11 squamous cell carcinomas, 2 adenosquamous carcinoma, 1 large cell carcinoma, 1 small cell carcinoma, 1 pleomorphic carcinoma and 1 mucoepidermoid carcinoma. We statistically compared (1) the mean SUVmax of lung cancer between the groups with and without lymph node metastasis (2) the frequency of lymph node metastasis between higher and lower SUVmax of lung cancer groups that were classified by using the median SUVmax of lung cancer, and (3) evaluated the relationship between the SUVmax of lung cancer and frequency of lymph node metastases, and (4) correlations between the SUVmax of lung cancer and number of the metastatic lymph nodes and pathological n stages.

Results

The difference in the average of the SUVmax of lung cancer between the cases with and without lymph node metastases was statistically significant (p = 0.00513). Lymph node metastasis was more frequently seen in the higher SUVmax of lung cancer group (17/33, 52%) than in the lower SUVmax of lung cancer group (7/33, 21%) with a statistically significant difference. There was no lymph node metastasis in lung cancers with an SUVmax of lung cancer less than 2.5, and lung cancers with an SUVmax of lung cancer more than 12 had a 70% frequency of lymph node metastasis. There were moderate correlations between SUVmax of lung cancer, and the number of the metastatic lymph nodes (γ = 0.404, p = 0.001) and pathological n stage (γ = 0.411, p = 0.001).

Conclusions

The likelihood of lymph node metastasis increases with an increase of the SUV of a primary lung cancer.

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References

  1. Onishi H, Araki T, Shirato H, Nagata Y, Hiraoka M, Gomi K, et al. Stereotactic hypofractionated high-dose irradiation for stage I nonsmall cell lung carcinoma: clinical outcomes in 245 subjects in a Japanese multiinstitutional study. Cancer 2004;101:1623–31.

    Article  PubMed  Google Scholar 

  2. Onishi H, Shirato H, Nagata Y, Hiraoka M, Fujino M, Gomi K, et al. Hypofractionated stereotactic radiotherapy (HypoFXSRT) for stage I non-small cell lung cancer: updated results of 257 patients in a Japanese multi-institutional study. J Thorac Oncol. 2007;7:94–100.

    Article  Google Scholar 

  3. Steinert HC, Hauser M, Allemann F, Engel H, Berthold T, von Schulthess GK, et al. Non-small cell lung cancer: nodal staging with FDG PET versus CT with correlative lymph node mapping and sampling. Radiology. 1997;202:441–6.

    PubMed  CAS  Google Scholar 

  4. Halter G, Buck AK, Schirrmeister H, Aksoy E, Liewald F, Glatting G, et al. Lymph node staging in lung cancer using [18F] FDG-PET. Thorac Cardiovasc Surg. 2004;52:96–101.

    Article  PubMed  CAS  Google Scholar 

  5. von Haag DW, Follette DM, Roberts PF, Shelton D, Segel LD, Taylor T. Advantages of positron emission tomography over computed tomography in mediastinal staging of non-small cell lung cancer. J Surg Res. 2002;103:160–4.

    Article  Google Scholar 

  6. Lardinois D, Weder W, Hany TF, Kamel EM, Korom S, Seifert B, et al. Staging of non-small-cell lung cancer with integrated positron-emission tomography and computed tomography. N Engl J Med. 2003;348:2500–7.

    Article  PubMed  Google Scholar 

  7. Shim SS, Lee KS, Kim BT, Chung MJ, Lee EJ, Han J, et al. Non-small cell lung cancer: prospective comparison of integrated FDG PET/CT and CT alone for preoperative staging. Radiology. 2005;236:1011–9.

    Article  PubMed  Google Scholar 

  8. Kim BT, Lee KS, Shim SS, Choi JY, Kwon OJ, Kim H, et al. Stage T1 non-small cell lung cancer: preoperative mediastinal nodal staging with integrated FDG PET/CT—a prospective study. Radiology. 2006;241:501–9.

    Article  PubMed  Google Scholar 

  9. Fischer BM, Mortensen J. The future in diagnosis and staging of lung cancer: positron emission tomography. Respiration. 2006;73:267–76.

    PubMed  Google Scholar 

  10. Kim YK, Lee KS, Kim BT, Choi JY, Kim H, Kwon OJ, et al. Mediastinal nodal staging of nonsmall cell lung cancer using integrated 18F-FDG PET/CT in a tuberculosis-endemic country: diagnostic efficacy in 674 patients. Cancer. 2007;109:1068–77.

    Article  PubMed  Google Scholar 

  11. Konishi J, Yamazaki K, Tsukamoto E, Tamaki N, Onodera Y, Otake T, et al. Mediastinal lymph node staging by FDG-PET in patients with non-small cell lung cancer: analysis of false-positive FDG-PET findings. Respiration. 2003;70:500–6.

    Article  PubMed  Google Scholar 

  12. Ohtsuka T, Nomori H, Watanabe K, Naruke T, Orikasa H, Yamazaki K, et al. False-positive findings on [18F]FDG-PET caused by non-neoplastic cellular elements after neoadjuvant chemoradiotherapy for non-small cell lung cancer. Jpn J Clin Oncol. 2005;35:271–3.

    Article  PubMed  Google Scholar 

  13. Chang JM, Lee HJ, Goo JM, Lee HY, Lee JJ, Chung JK, et al. False positive and false negative FDG-PET scans in various thoracic diseases. Korean J Radiol. 2006;7:57–69.

    Article  PubMed  Google Scholar 

  14. Melek H, Gunluoglu MZ, Demir A, Akin H, Olcmen A, Dincer SI. Role of positron emission tomography in mediastinal lymphatic staging of non-small cell lung cancer. Eur J Cardiothorac Surg. 2008;33:294–9.

    Article  PubMed  Google Scholar 

  15. Higashi K, Ito K, Hiramatsu Y, Ishikawa T, Sakuma T, Matsunari I, et al. 18F-FDG uptake by primary tumor as a predictor of intratumoral lymphatic vessel invasion and lymph node involvement in non-small cell lung cancer: analysis of a multicenter study. J Nucl Med. 2005;46:267–73.

    PubMed  Google Scholar 

  16. Ohtsuka T, Nomori H, Watanabe K, Kaji M, Naruke T, Suemasu K, et al. Prognostic significance of [(18)F]fluorodeoxyglucose uptake on positron emission tomography in patients with pathologic stage I lung adenocarcinoma. Cancer. 2006;107:2468–73.

    Article  PubMed  Google Scholar 

  17. Berghmans T, Dusart M, Paesmans M, Hossein-Foucher C, Buvat I, Castaigne C, et al. Primary tumor standardized uptake value (SUVmax) measured on fluorodeoxyglucose positron emission tomography (FDG-PET) is of prognostic value for survival in non-small cell lung cancer (NSCLC): a systematic review and meta-analysis (MA) by the European Lung Cancer Working Party for the IASLC Lung Cancer Staging Project. J Thorac Oncol. 2008;3:6–12.

    Article  PubMed  Google Scholar 

  18. Hellwig D, Graeter TP, Ukena D, Groeschel A, Sybrecht GW, Schaefers HJ, et al. 18F-FDG PET for mediastinal staging of lung cancer: which SUV threshold makes sense? J Nucl Med. 2007;48:1761–6.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, University of Yamanashi, 1110 Shimokawato, Chuo, Yamanashi, 409-3898, Japan

    Atsushi Nambu, Satoshi Kato, Tomoaki Ichikawa & Tsutomu Araki

  2. Department of Radiology, Kofu Neuro Surgical Hospital, Yamanashi, Japan

    Yoko Sato

  3. Second Department of Surgery, University of Yamanashi, Yamanashi, Japan

    Hideto Okuwaki

  4. Second Department of Internal Medicine, University of Yamanashi, Yamanashi, Japan

    Keiichi Nishikawa

  5. Department of Radiology, Yamanashi Prefectural Hospital, Yamanashi, Japan

    Akitoshi Saito

  6. Department of Radiology, Kobe University Graduate School of Medicine, Hyogo, Japan

    Keiko Matsumoto

Authors
  1. Atsushi Nambu
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  2. Satoshi Kato
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  3. Yoko Sato
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  4. Hideto Okuwaki
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  5. Keiichi Nishikawa
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  6. Akitoshi Saito
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  7. Keiko Matsumoto
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  8. Tomoaki Ichikawa
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  9. Tsutomu Araki
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Correspondence to Atsushi Nambu.

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Nambu, A., Kato, S., Sato, Y. et al. Relationship between maximum standardized uptake value (SUVmax) of lung cancer and lymph node metastasis on FDG-PET. Ann Nucl Med 23, 269–275 (2009). https://doi.org/10.1007/s12149-009-0237-5

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  • DOI: https://doi.org/10.1007/s12149-009-0237-5

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