Abstract
Histiocytic sarcoma is a rare malignancy of hematopoietic origin. Lymph nodes, skin, and extranodal sites, especially gastrointestinal tract, are commonly involved. Some cases reported in the past as non-Hodgkin’s lymphoma are now classifi ed as histiocytic sarcoma by detailed immunohistochemical studies. Patients with clinically localized disease have a good prognosis whereas those with lymphatic involvement have an aggressive course. In our case, histiocytic sarcoma was detected, originating from the skin over the left shoulder associated with disseminated lymphadenopathy. A positron emission tomography/computed tomography examination was done for evaluating the extent of the disease which showed pathologic increased 18F-fl uorodeoxyglucose uptake in the lymph nodes, indicating widespread disease. The pertinent literature is reviewed.
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References
Jaffe ES, Harris NL, Stein H, Vardiman JW. World Health Organization classifi cation of tumors: pathology and genetics of tumours of hematopoietic and lymphoid tissues. Lyon: IARC; 2001.
Mirchandani I, Shah I, Palutke M, Varadachari C, Tabaczka P, Franklin R, et al. True histiocytic lymphoma: a report of four cases. Cancer 1983;52:1911–1918.
Van der Valk P, Van Oostveen JW, Stel HV, Van der Kwast TH, Melief CJ, Meijer CJ. Phenotypic and genotypic analysis of large-cell lymphomas, formerly classifi ed as true histiocytic lymphoma: identifi cation of an unusual group of tumors. Leuk Res 1990;14:337–346.
Van Heerde P, Feltkamp CA, Hart AA, Somers R, Van Unnik JA, Vroom TM. Malignant histiocytosis and related tumors: a clinicopathologic study of 42 cases using cytological, histochemical and ultrastructural parameters. Hematol Oncol 1984;2:13–32.
Pileri SA, Grogan TM, Harris NL, Banks P, Campo E, Chan JK, et al. Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classifi cation from the International Lymphoma Study Group based on 61 cases. Histopathology 2002;41:1–29.
Hornick JL, Jaffe ES, Fletcher CDM. Extranodal histiocytic sarcoma: clinicopathologic analysis of 14 cases of a rare epithelioid malignancy. Am J Surg Pathol 2004;28:1133–1144.
Buonocore S, Valente AL, Nightingale D, Bogart J, Souid A. Histiocytic sarcoma in a 3-year-old male: a case report. Pediatrics 2005;116:e322–e325.
Juweid ME, Stroobants S, Hoekstra OS, Mottaghy FM, Dietlein M, Guermazi A, et al. Use of positron emission tomography for response assessment of lymphoma: consensus of the Imaging Subcommittee of International Harmonization Project in Lymphoma. J Clin Oncol 2007;25:571–578.
Blum R, Seymour JF, Hickks RJ. Role of FDG-positron emission tomography scanning in the management of histiocytosis. Leuk Lymphoma 2002;43:2155–2157.
Kaste SC, Rodriguez-Galindo C, McCraville ME, Shulkin BL. PET-CT in pediatric Langerhans cell histiocytosis. Pediatr Radiol 2007;37:615–622.
Weiss SE, O’Connor L, Welsh JS. Refi nement of radiation therapy based on PET data in adults with Langerhans cell histiocytosis of soft tissues. Clin Adv Hematol Oncol 2006;4:290–294.
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Yaman, E., Ozturk, B., Erdem, O. et al. Histiocytic sarcoma: PET-CT evaluation of a rare entity. Ann Nucl Med 22, 715–717 (2008). https://doi.org/10.1007/s12149-008-0175-7
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DOI: https://doi.org/10.1007/s12149-008-0175-7