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Histiocytic sarcoma arising from a lymph node: a diagnostic conundrum

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Abstract

Histiocytic Sarcoma (HS) is extremely rare, with only a few hundred cases reported in the literature. The majority of patients present with symptoms due to unifocal or multifocal extra-nodal disease. Less than 20% of these cases show solitary involvement of a lymph node. We report a case of a solitary HS in a 53-year-old woman presenting with a 2.7-cm right groin mass arising from an inguinal lymph node. The initial cytologic examination of the tissue showed a high-grade spindle-shaped morphology with high-grade mitotic activity. A high-grade sarcoma was initially considered considering the absence of normal lymphoid aggregate and the presence of high-grade cytologic features in the cells. To evaluate the tumor in its entirety, the mass was surgically excised. A histological examination of the tumor showed focal rimming of the lymphoid tissue at the periphery and a centrally located stellate necrotic focus. The tumor cells had an epithelioid to spindle cell morphology along with large uniform nuclei and prominent nucleoli. A high mitotic index was present. Immunohistochemistry (IHC) stains showed strong positivity for CD68, CD163, and Vimentin, and were weakly positive for SMA and CD45. Based on the histologic and clinical examination, a diagnosis of HS was made. Multiple malignancies can mimic HS histopathology and the rarity of this tumor makes the diagnosis more challenging. No fine-needle aspiration (FNA) criteria for its diagnosis have been recognized. Herein, we report a rare case of an isolated HS involving a lymph node which resembled high-grade sarcoma on the FNA biopsy to raise awareness among our surgical pathologist colleagues.

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Authors and Affiliations

  1. Department of Pathology, The University of Oklahoma Health Science Center, Oklahoma City, OK, USA

    Anoshia Afzal

  2. Department of Dermatopathology, McGaw Medical Center of Northwestern University, Suite 1600, 676 North Saint Clair Street, Chicago, IL, 60611, USA

    Sepideh N. Asadbeigi

  3. Department of Neurology, Dow University of Health Sciences, Karachi, Pakistan

    Umar Farooque

  4. Department of Psychology, University of Tulsa, Tulsa, OK, USA

    Christy Mather

  5. Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, USA

    Shahbaz Khan

Authors
  1. Anoshia Afzal
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  2. Sepideh N. Asadbeigi
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  3. Umar Farooque
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  4. Christy Mather
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  5. Shahbaz Khan
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Correspondence to Sepideh N. Asadbeigi.

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Afzal, A., Asadbeigi, S.N., Farooque, U. et al. Histiocytic sarcoma arising from a lymph node: a diagnostic conundrum. Int Canc Conf J 10, 244–247 (2021). https://doi.org/10.1007/s13691-021-00489-9

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  • DOI: https://doi.org/10.1007/s13691-021-00489-9

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