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Gas-phase separation using a trapped ion mobility spectrometer

  • Original Research
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International Journal for Ion Mobility Spectrometry

Abstract

In the present work we describe the principles of operation, versatility and applicability of a trapped ion mobility spectrometer (TIMS) analyzer for fast, gas-phase separation of molecular ions based on their size-to-charge ratio. Mobility-based separation using a TIMS device is shown for a series for isobar pairs. In a TIMS device, mobility resolution depends on the bath gas velocity and analysis scan speed, with the particularity that the mobility separation can be easily tuned from low to high resolution (R > 50) in accordance with the analytical challenge . In contrast to traditional drift tube IMS analyzer, a TIMS device can be easily integrated in a mass spectrometer without a noticeable loss in ion transmission or sensitivity, thus providing a powerful separation platform prior to mass analysis.

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Acknowledgments

This work was supported by the National Institute of Health (Grant No. 1K99RR030188-01) and a 2010&2011 Bruker Daltonics, Inc. Fellowship.

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Authors and Affiliations

  1. Department of Chemistry, Texas A&M University, MS 3144, College Station, TX, 77843–3144, USA

    Francisco Fernandez-Lima

  2. Bruker Daltonics, Inc., Billerica, MA, USA

    Desmond A. Kaplan & Melvin A. Park

  3. Bruker Daltonik gmbH, Bremen, Germany

    J. Suetering

Authors
  1. Francisco Fernandez-Lima
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  2. Desmond A. Kaplan
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  3. J. Suetering
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  4. Melvin A. Park
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Correspondence to Francisco Fernandez-Lima.

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Fernandez-Lima, F., Kaplan, D.A., Suetering, J. et al. Gas-phase separation using a trapped ion mobility spectrometer. Int. J. Ion Mobil. Spec. 14, 93–98 (2011). https://doi.org/10.1007/s12127-011-0067-8

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  • DOI: https://doi.org/10.1007/s12127-011-0067-8

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