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Reference Values of Serum Cystatin-C for Full-Term and Preterm Neonates in Istanbul

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Abstract

Objective

To determine the level and distribution of Cystatin C values in full-term and preterm healthy neonates for the purpose of diagnosis and follow-up of renal diseases of the neonates.

Methods

Eighty-eight newborn infants, including 55 preterm and 33 term born in the authors’ hospital having no urinary tract pathology, symptoms or signs during prenatal and postnatal follow-up, were studied .

Results

There were 25 neonates born between gestational wk of 28 and 32 (Group 1), 30 neonates born between gestational wk of 33–36 (Group 2) and 33 neonates born after gestational wk of 37 (Group 3). Average cystatin C values were determined to be 1.41 mg/l, 1.22 mg/l and 1.21 mg/l for Group 1, Group 2 and Group 3, respectively.

Conclusions

Evalution of cystatin C can be effective for follow-up of renal pathologies, because it is not affected by gender, body weight and muscle mass and has a constant production rate.

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References

  1. Potter EL. Normal development of the kidney. In: Potter EL, editor. Normal and abnormal development of the kidney. Chicaco: Year Book Medical Publishers; 1972. p. 3–79.

    Google Scholar 

  2. Sever L. Yenidoğanın Böbrek ve Üriner Sistem Hastalıkları. In: Dağoğlu T, Ovalı F, editors. Neonatoloji. 2nd ed. İstanbul: Nobel Tıp kitapevleri; 2007. p. 681–7005.

    Google Scholar 

  3. Guillery EN, Nuyt AMÖ, Robillard JE. Functionel development of the kidney inutero. In: Polin RA, Fox WW, editors. Fetal and neonatal physiology. Philadelphia: W.B. Saunders Company; 1998. p. 1560–73.

    Google Scholar 

  4. Grubb A. Diagnostic value of analysis of cystatin C and protein HC in biological fluids. Clin Nephrol. 1992;38:20–7.

    Google Scholar 

  5. Tenstad O, Roald AB, Grubb A, et al. Renal hendling of radiolabelled human cystatin C in the rat. Scand J Clin Lab Invest. 1996;56:409–14.

    Article  PubMed  CAS  Google Scholar 

  6. Jacobbson B, Lignelid H, Bergerheim USR. Transthyretin and cystatin C are catabolized in proximal tubular epithelial cells and the proteins are not useful as markers for renal cell carcinoma. Histopathol. 1995;26:559–64.

    Article  Google Scholar 

  7. Fetterman GH, Shuplock NA, Phillip FJ, Gregg HS. The growth and maturation of human glomeruli and proximal convolutions from term to adulthood: studies by microdissection. Pediatrics. 1965;35:601–19.

    PubMed  CAS  Google Scholar 

  8. Schwartz GJ. Clinical assessment of renal function. In: Kher KK, Schnaper HW, Makker SP, editors. Clinical pediatric nephrology. New York: Mc-Graw-Hill Inc; 2007. p. 71–93.

    Google Scholar 

  9. Brion LP, Satin LM, Edelmann CM. Renal disease. In: Avery GB, Fletcher MAi MacDonald MG, editors. Neonatology-pathophysiology and management of the newborn. 5th ed. Philadelphia: Lippincott Williams&Wilkins; 1999. p. 887–973.

    Google Scholar 

  10. Pentikaeinan FA. Tip 2 Diabetik Hastaların Böbrek Fonksiyonlarının Değerlendirilmesinde Serum Sistatin C, B2 Mikroglobulin. Kreatinin Değerlerinin Karşılaştırılması: Uzmanlık tezi, İstanbul; 2005.

    Google Scholar 

  11. Fawer C-L. Torrado, Guignard J-P. Maturation of renal function in full-term and premature neonates. Helv Paediatr Acta. 1979;34:11–21.

    PubMed  CAS  Google Scholar 

  12. Fanos V, Mussap M, Plebani M, Cataldi L. Cystatin C in paediatric nephrology. Present situation and prospects. Minevra Pediatr. 1999;51:167–77.

    CAS  Google Scholar 

  13. Kristensen K, Strevens H, Lindström V, Grubb A, Wide-Swensson D. Increased plasma levels of beta2-microglobulin, cystatin C and beta-trace protein in term pregnancy are not due to utero-placental production. Scand J Clin Lab Invest. 2008;68:649–53.

    Article  PubMed  CAS  Google Scholar 

  14. Feldman H, Guignard JP. Plasma creatinine in the first month of life. Arch Dis Child. 1982;57:123–6.

    Article  PubMed  CAS  Google Scholar 

  15. Bahar A, Yilmaz Y, Unver S, Gocmen I, Karademir F. Reference values of umbilical cord and third-day cystatin c levels for determining glomerular filtration rates in newborns. J Internat Med Res. 2003;31:231–5.

    CAS  Google Scholar 

  16. Finney H, Newman DJ, Thakkar H, Fell JM, Price CP. Reference ranges for plasma cystatin C and creatinine measurements in premature infants, neonates, and older children. Arch Dis Child. 2000;82:71–5.

    Article  PubMed  CAS  Google Scholar 

  17. Harmoinen A, Ylinen E, Ala-Houhala M, Janas M, Kaila M, Kouri T. Reference intervals for cystatin C in pre- and full-term infants and children. Pediatr Nephrol. 2000;15:105–8.

    Article  PubMed  CAS  Google Scholar 

  18. Bökenkamp A, Domanetzki M, Zinck R, Schumann G, Brodehl J. Reference values for cystatin C serum concentrations in children. Pediatr Nephrol. 1998;12:125–9.

    Article  PubMed  Google Scholar 

  19. Sonntag J, Prankel B, Waltz S. Serum creatinine concentration, urinary creatinine excretion and creatinine clearance during the first 9 weeks in preterm infants with a birth weight below 1500 g. Eur J Pediatr. 1996;155:815–9.

    Article  PubMed  CAS  Google Scholar 

  20. Erlandsen EJ, Randers E, Kristensen JH. Evaluation of the N Latex Cystatin C assay on the Dade Behring Nephelometer II system. Scand J Clin Lab Investig. 1999;59:1–8.

    CAS  Google Scholar 

  21. Piepsz A, Pintelon H, Ham HR. Estimation of normal chromium-51 ethylene diamine tetra-acetic acid clearance in children. Eur J Nucl Med. 1994;21:12–6.

    Article  PubMed  CAS  Google Scholar 

  22. Heijden AJ, Grose WFA, Ambagtsheer JJ, Provoost AP, Wolff ED, Sauer PJJ. Glomerular filtration rate in the preterm infant: the relation to gestational and postnatal age. Eur J Pediatr. 1988;148:24–8.

    Article  PubMed  Google Scholar 

  23. Gordjani N, Burghard R, Leititis JU, Brandis M. Serum creatinine and creatinine clearance in healthy neonates and prematures during the first 10 days of life. Eur J Pediatr. 1988;148:143–5.

    Article  PubMed  CAS  Google Scholar 

  24. Schwartz GJ, Brion LP. The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children and adolescents. Pediatr Clin North Am. 1987;34:571–90.

    PubMed  CAS  Google Scholar 

  25. Aperia A, Broberger O, Elinder G, Herin P, Zetterström R. Postnatal development of renal function in pre-term and full-term infants. Acta Paediatr Scand. 1981;70:183–7.

    Article  PubMed  CAS  Google Scholar 

  26. Brion LP, Fleischmann AR, McCarton C, Schwartz GJ. A simple estimate of glomerular filtration rate in low weight infants during the first year of life: noninvasive assessment of body composition and growth. J Pediatr. 1986;109:698–707.

    Article  PubMed  CAS  Google Scholar 

  27. Herget-Rosenthal S, Trabold S, Pietruck F, Holtmann M, Philipp T, Kribben A, Cystatin C. Efficacy as screening test for reduced glomerular filtration rate. Am J Nephrol. 2000;20:97–102.

    Article  PubMed  CAS  Google Scholar 

  28. Randers E, Krue S, Erlandsen EJ, Danielsen H, Hansen LG. Reference interval for serum cystatin c in children. Clin Chem. 1999;45:1856–8.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, Sevket Yilmaz Education and Research Hospital, Bursa, Turkey

    Sevil Dorum & Bayram Ali Dorum

  2. Department of Pediatrics, Mustafa Kemal University, Faculty of Medicine, Mustafa Kemal Universitesi tip fakultesi cocuk sag. ve hast. ABD, Antakya, Hatay, Turkey

    Ibrahim Silfeler

  3. Department of Obstetrics and Gynecology, Mustafa Kemal University, Faculty of Medicine, Antakya, Hatay, Turkey

    Dilek B. Silfeler

  4. Department of Pediatrics, Fatih Sultan Mehmet Education and Research Hospital, Istanbul, Turkey

    Yekta Canbak

  5. Department of Pediatrics, Zeynep Kamil Women and Children Diseases Education and Research Hospital, Uskudar, Istanbul, Turkey

    Aysu Say

  6. urgenpasa mah. sehitsabri aksu sok. ece apt. no:21 kat:5 D:22, Antakya, Hatay, Turkey

    Ibrahim Silfeler

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  1. Sevil Dorum
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  2. Ibrahim Silfeler
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  5. Yekta Canbak
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Correspondence to Ibrahim Silfeler.

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Dorum, S., Silfeler, I., Dorum, B.A. et al. Reference Values of Serum Cystatin-C for Full-Term and Preterm Neonates in Istanbul. Indian J Pediatr 79, 1037–1042 (2012). https://doi.org/10.1007/s12098-011-0655-y

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  • DOI: https://doi.org/10.1007/s12098-011-0655-y

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