Abstract
Presented here is a report of 3 children, out of 66 total pediatric Hodgkin’s lymphoma (HL) patients (4.5%) with bone involvement over a 3 and a half year period. Two patients presented with osseous lesions at the time of relapse and one had concurrent evidence of non-osseous disease. The clinical presentation, radiographic findings, histology, treatment and outcome of these patients are discussed. Boys and girls are nearly equally affected, local bone pain is the commonest symptom and B-symptoms are common. Vertebrae and pelvis are most frequently involved, commonly with an osteolytic picture. Nodular sclerosis is the predominant histological subtype. Most children received combined modality treatment and the overall response and survival are good.
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Newcomer LN, Silverstein MB, Cadman EC, Farber LR, Bertino JR, Prosnitz LR. Bone involvement in Hodgkin’s disease. Cancer 1982;49:338–342
Ostrowski ML, Unni KK, Banks PM, Shives TC, Evans RG, O’Connell MJ et al. Malignant lymphoma of bone. Cancer 1986; 58: 2646–2655.
Ostrowski ML, Inwards CY, Strickler JG, Witziq TE, Wenger DE, Unni KK. Osseous Hodgkin’s disease. Cancer 1999; 5: 1166–1178.
Gross SB, Robertson WW Jr., Lange BJ, Bunin NJ, Drummond DS. Primary Hodgkin’s disease of bone: a report of two cases in adolescents and review of the literature. Clin Orthop 1992; 283: 276–280.
Chan K-W, Rosen G, Miller DR, Tan CTC. Hodgkin’s disease in adolescents presenting as a primary bone lesion: a report of four cases and review of the literature. Am J Pediatr Hematol Oncol 1982;4: 11–17.
Köseoglu RD, Senayli A, Biçakçi U, Onuk-Filiz N, Sezer T, Celkan T. Osseous presentation of Hodgkin’s disease: a case report and review of the literature. Turk J Pediatr 2007;49: 218–222.
Mandell GA. Resolution of Hodgkin’s induced ivory vertebrae. Pediatr Radiol 1978; 7: 178–179.
Appell RG, Oppermann HC, Brandeis WE. Skeletal lesions in Hodgkin’s disease. Review of literature and case reports. Pediatr Radiol 1981;11: 61–65.
Sullivan WT, Solonick DM. Case report 414: nodular sclerosing Hodgkin disease involving sternum and chest wall. Skeletal Radiol 1987;16:166–169.
Ozdemirli M, Mankin HJ, Aisenberg AC, Harris NL. Hodgkin’s disease presenting as a solitary bone tumor. Cancer 1996;77:79–88.
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Singh, P., Bakhshi, S. Osseous involvement in pediatric Hodgkin’s lymphoma. Indian J Pediatr 77, 565–566 (2010). https://doi.org/10.1007/s12098-010-0019-z
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DOI: https://doi.org/10.1007/s12098-010-0019-z