Abstract
Skeletal lesions in Hodgkin's disease can be due to different underlying causes. Reports on bone changes in Hodgkin's disease are reviewed and compared with two of our patients. The first patients, a fourteen year old girl with Hodgkin's disease, staged IV B, had skeletal involvement at the time of diagnosis. The other patient developed, three and a half years after the onset of the disease, bone lesions which might have been thought to be a manifestation of Hodgkin's disease. But by bacteriologic and histologic studies salmonella osteomyelitis could be proven.
Similar content being viewed by others
References
Arseneau JC, Sponzo RW, Levin DL, Schnipper LE, Bonner H, Young RC, Canellos GP, Johnson RE, DeVita VT (1972) Nonlymphomatous malignant tumors complicating Hodgkin's disease. N Engl J Med 287: 1119
Arseneau JC, Canellos GP, Johnson R, DeVita VT (1977) Risk of new cancers in patients with Hodgkin's disease. Cancer 40: 1912
Askanazy M (1920) Lymphogranulom des Knochenmarks. Zentralbl Allg Pathol 31: 557
Beachley MC, Lau BP, King ER (1972) Bone involvement in Hodgkin's disease. AJR 114: 559
Benz G, Brandeis WE, Willich E (1976) Radiological aspects of leukemia in childhood. Pediatr Radiol 4: 201
Braunstein EM (1980) Hodgkin disease of bone: Radiographic correlation with the histological classification. Radiology 137: 643
Canellos GP, DeVita VT, Arseneau JC, Whang-Peng J, Johnson REC (1975) Second malignancies complicating Hodgkin's disease in remission. Lancet I: 947
Craver LF, Copeland MM (1934) Changes in the bone in Hodgkin's granuloma. Arch Surg 28: 1062
Dahlin DC, Coventry MB, Scanlon PW (1961) Ewing's sarcoma. A critical analysis of 165 cases. J Bone Joint Surg [Am] 43: 185
Davis LA (1968) Antibiotic modified osteomyelitis. AJR 103: 608
DeVita VT, Serpick AA, Carbone PP (1970) Combination chemotherapy in the treatment of advanced Hodgkin's disease. Ann Intern Med 73: 881
Dresser R (1931) Lymphogranulomatose der Knochen. Strahlentherapie 41: 401
Echeverria J, Kaude JV (1978) Multifocal tuberculous osteomyelitis. Pediatr Radiol 7: 238
Ennis JT, Whitehouse G, Ross FGM, Middlemiss JH (1973) The radiology of the bone changes in Histiocytosis X. Clin Radiol 24: 212
Ferrant A, Rodhain J, Michaux JL, Piret L, Maldague B, Sokal G (1975) Detection of skeletal involvement in Hodgin's disease: a comparison of radiography, bone scanning, and bone marrow biopsy in 38 patients. Cancer 35: 1346
Fischer AM, Kendall B, Van Leuven BD (1962) Hodgkin's disease: a radiological survey. Clin Radiol 13: 115
Fucilla IS, Hamann A (1961) Hodgkin's disease in bone. Radiology 77: 53
Garré C (1893) Über besondere Formen und Folgezustände der akuten infektiösen Osteomyelitis. Bruns Beitr Klin Chir 10: 241
Granger W, Whitaker R (1967) Hodgkin's disease in bone, with special reference to periosteal reaction. Br J Radiol 40: 939
Grossmann A, Weis-Osthorn W (1922) Ein Fall von Paltauf-Sternberschem Lymphogranulom mit röntgenologisch nachweisbarer Veränderung der Beckenknochen. RÖFO 29: 569
Heldrich R, Harris V (1979) Osteomyelitis of the publis. Acta Paediatr Scand 68: 39
Hope-Stone HF (1979) The diagnosis of osteo-necrosis in Hodgkin's disease — active disease or infarction? Br J Radiol 52: 580
Ihde DC, DeVita VT (1975) Osteonecrosis of the femoral head in patients with lymphoma treated with intermittent combination chemotherapy (including corticosteroids). Cancer 36: 1585
Kay CJ, Rosenberg MA, Burd R (1974) Hypertrophic osteoarthropathy and childhood Hodgkin's disease. Radiology 112: 177
Kim JH, Chu FC, Woodard HQ, Melamed MR, Huvos A, Cantin J (1978) Radiation-induced soft-tissue and bone sarcoma. Radiology 129: 501
Kushner DC, Weinstein HJ, Kirkpatrick JA (1980) The radiologic diagnosis of leukemia and lymphoma in children. Semin Roentgenol 15: 316
Mandell GA (1978) Resolution of Hodgkin's induced ivory vertebrae. Pediatr Radiol 7: 178
McCullogh CJ (1980) Eosinophilic granuloma of bone. Acta Orthop Scand 51: 389
Meher-Homji DR, De Souza LJ, Mohanty B, Culcuttawalla TF (1972) Unusual sternal mass in Hodgkin's disease. J Bone Joint Surg [Am] 54: 402
Morris LL, Cassady JR, Jaffe N (1975) Sternal changes following mediastinal irradiation for childhood Hodgkin's disease. Radiology 115: 701
Musshoff K, Busch M, Kaminski H (1965) Lymphogranulomatose (Morbus Hodgkin) mit Knochenbefall — Symptomatologie mit besonderer Berücksichtigung des Röntgenbildes, Therapie und Prognose. RÖFO 101: 117
Parker BR, Castellino RA, Kaplan HS (1976) Pediatric Hodgkin's disease. I. Radiographic evaluation. Cancer 37: 2430
Parker BR, Castellino RA (1977) Pediatric oncologic radiology. CV Mosby, Saint Louis
Sahakian GJ, Al-Mondhiry H, Lacher MJ, Conolly CE (1974) Acute leukemia in Hodgkin's disease. Cancer 33: 1369
Sitarz AL, Berdon WE, Wolff JA, Baker DH (1980) Acute lymphocytic leukemia masquerading as acute osteomyelitis. Pediatr Radiol 9: 33
Slovis ThL, Haller JO, Berdon WE, Baker DH (1973) Aseptic necrosis of the femoral head in a white boy with S-D hemoglobinopathy. Pediatr Radiol 1: 250
Smith J, O'Connell RS, Huvos AG, Woodard HQ (1980) Hodgkin's disease complicated by radiation sarcoma in bone. Br J Radiol 53: 314
Stuhlbarg J, Ellis FW (1965) Hodgkin's disease of bone —Favorable prognostic significance? AJR 93: 568
Sweet DL, Kinnealey A, Ultmann JE (1978) Hodgkin's disease: problems of staging. Cancer 42: 957
Tan C, D'Angio GJ, Exelby PR, Liebermann PH, Watson RC, Cham WC, Murphy ML (1975) The changing management of childhood Hodgkin's disease. Cancer 35: 808
Timothy AR, Tucker AK, Park WM, Cannell LB (1978) Osteonecrosis in Hodgkin's disease. Br J Radiol 51: 328
Uehlinger E (1933) Über Knochen-Lymphogranulomatose. Virchows Arch [Pathol Anat] 288: 36
Vieta JO, Friedell HL, Craver LF (1942) A survey of Hodgkin's disease and lymphosarcoma in bone. Radiology 39: 1
Waldvogel FA, Medoff G, Swartz MN (1970) Osteomyelitis: a review of clinical features, therapeutic considerations and unusual aspects. N Engl J Med 282: 198, 260, 316
Weber WG, DeNardo GL, Berin JJ (1968) Scintiscanning in malignant lymphomatous involvement of bone. Arch Intern Med 121: 433
Zenny JC, Aim D, Grenier Ph, Bernard JF, Nahum H (1980) Les localisations sternales de la maladie de Hodgkin. A propos de deux cas. J Radiol 61: 281
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Appell, R.G., Oppermann, H.C. & Brandeis, W.E. Skeletal lesions in Hodgkin's disease. Pediatr Radiol 11, 61–65 (1981). https://doi.org/10.1007/BF00971780
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00971780