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NIMA-related kinase-6 (NEK6) as an executable target in cancer

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Abstract

Cancer is a disease that develops when cells begin to divide uncontrollably and spreads to other parts of the body. Proliferation and invasion of cancerous cells are generally known to be influenced by cell cycle-related proteins in human malignancies. Therefore, in this review, we have emphasized on the serine/threonine kinase named NEK6. NEK6 is been deliberated to play a critical role in mitosis progression that includes mitotic spindle formation, metaphase to anaphase transition, and centrosome separation. Moreover, it has a mechanistic role in DNA repair and can cause apoptosis when inhibited. Past studies have connected NEK6 protein expression to cancer cell senescence. Besides, there are reports relating NEK6 to a range of malignancies including breast, lung, ovarian, prostate, kidney, liver, and others. Given its significance, this review attempts to describe the structural and functional aspects of NEK6 in various cellular processes, as well as how it is linked to different forms of cancer. Lastly, we have accentuated, on some of the plausible inhibitors that have been explored against NEK6 overexpression.

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Acknowledgements

The authors are thankful to the Vellore Institute of Technology, Vellore, India for providing the necessary facilities to carry out this work.

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  1. Department of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, 632014, India

    Nagesh Kishan Panchal, Shruti Mohanty & Sabina Evan Prince

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NKP conceptualization, literature survey, writing–original draft. SM conceptualization, literature survey, writing–original draft. SEP conceptualization, supervision, writing–original draft.

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Panchal, N.K., Mohanty, S. & Prince, S.E. NIMA-related kinase-6 (NEK6) as an executable target in cancer. Clin Transl Oncol 25, 66–77 (2023). https://doi.org/10.1007/s12094-022-02926-4

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