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Effectiveness of oxaliplatin desensitization protocols

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Abstract

Introduction

Hypersensitivity reaction (HSR) to antineoplastic drugs can force doctors to stop treatment and seek other alternatives. These alternatives may be less effective, not as well tolerated and/or more expensive. Another option is to use desensitization protocols that induce a temporary state of tolerance by gradually administering small quantities of the antineoplastic drug until the therapeutic dosage is reached. The aim of this study is to assess the effectiveness of oxaliplatin desensitization protocols.

Materials and methods

A retrospective observational study was carried out between January 2006 and May 2011. The inclusion criteria were patients undergoing chemotherapy treatment with oxaliplatin who had developed an HSR to the drug and who were candidates for continuing the treatment using a desensitization protocol. The patients’ clinical records were reviewed and variables were gathered relating to the patient, the treatment, the HSR, and the desensitization protocol administered. The data were analysed using version 18.0 of the statistics program SPSS.

Results

A total of 53 desensitization protocols were administered to 21 patients. In 89 % of these cases, no new reactions occurred while the drug was being administered. New reactions of mild severity only occurred in 11 % of cases, and none of these reactions were severe enough for treatment to be stopped. All patients were able to complete the desensitization protocol.

Conclusion

This study confirms that oxaliplatin desensitization protocols are safe and effective and allow patients to continue with the treatment that initially caused an HSR.

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Conflict of interest

The authors declare that they have no conflict of interest relating to the publication of this manuscript.

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Authors and Affiliations

  1. Department of Pharmacy, Hospital Universitario 12 de Octubre, Avda Cordoba s/n, 28041, Madrid, Spain

    Susana Cortijo-Cascajares, María José Aguilella-Vizcaíno & Alberto Herreros-de-Tejada

  2. Department of Pharmacy, Hospital San Juan de la Cruz, Úbeda, Jaén, Spain

    Inmaculada Nacle-López

  3. Department of Oncology, Hospital Universitario 12 de Octubre, Madrid, Spain

    Ignacio García-Escobar & Hernán Cortés-Funes Castro

  4. Department of Pharmacy, Hospital Virgen de las Nieves, Granada, Spain

    Miguel-Ángel Calleja-Hernández

Authors
  1. Susana Cortijo-Cascajares
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  2. Inmaculada Nacle-López
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  3. Ignacio García-Escobar
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  4. María José Aguilella-Vizcaíno
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  5. Alberto Herreros-de-Tejada
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  6. Hernán Cortés-Funes Castro
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  7. Miguel-Ángel Calleja-Hernández
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Corresponding author

Correspondence to Susana Cortijo-Cascajares.

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Cortijo-Cascajares, S., Nacle-López, I., García-Escobar, I. et al. Effectiveness of oxaliplatin desensitization protocols. Clin Transl Oncol 15, 219–225 (2013). https://doi.org/10.1007/s12094-012-0909-9

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  • DOI: https://doi.org/10.1007/s12094-012-0909-9

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