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Daily schedule for high-dose-rate brachytherapy in postoperative treatment of endometrial carcinoma

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Abstract

Purpose

To analyze the results of daily high-dose-rate brachytherapy (HDRBT) on local control and toxicity in the postoperative treatment of endometrial carcinoma (EC).

Materials and methods

From January 2007 to September 2010, 112 patients were treated with HDRBT after surgery for EC. FIGO staging: 24-IA, 48-IB, 14-II, 12-IIIA, 2-IIIB, 8-IIIC1 and 4-IIIC2. Pathology 99/112 endometrioid and 23/112 other types. Radiotherapy patients were divided into two groups—Group 1 (70/112) consists of external beam irradiation (EBI) plus HDRBT (2 fractions of 5–6 Gy) and Group 2 (42/112) consists of HDRBT alone (4 fractions of 5–6 Gy). Toxicity evaluation RTOG scores for bladder and rectum, and the objective criteria of LENT-SOMA for vagina. Statistics bivariate analysis of Chi-square and Fisher exact tests.

Results

With a mean follow-up of 29.52 months (range 9.60–53.57) no patient developed vaginal-cuff relapse. In Group 1 early toxicity appeared in 9 % in rectum, 8.5 % in bladder (G1–G2) and 1.4 % in vagina (G1); late toxicity was present in 8.5 % in rectum (all G1–G2 but 1 G3) and in 25 % in vagina (all G1–G2 but one G4). In Group 2, 9.4 % developed G1–G2 bladder and 6.9 % acute vagina (G1–G2) toxicity. Only 2.3 % had a G1 rectal score and 6.9 % had G1–G2 as vaginal scores for late problems.

Conclusions

(1) Daily HDRBT using two fractions of 5–6 Gy after EBI and four fractions of 5–6 Gy as exclusive treatment was a safe regime. (2) Group 1 showed a higher incidence of late vaginal toxicity.

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Conflict of interest

There is no conflict of interest in relation to this manuscript.

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Authors and Affiliations

  1. Gynecological Cancer Unit, Radiation Oncology Department, ICMHO, Hospital Clinic, University of Barcelona, IDIBAPS, C/Villarroel 170, 08036, Barcelona, Spain

    Angeles Rovirosa, Izaskun Valduvieco, Antonio Herreros, Carlos Bautista, Ingrid Romera & Albert Biete

  2. Public Health Department, University of Barcelona, IDIBAPS, Barcelona, Spain

    Carlos Ascaso

  3. Medical Oncology Department, Hospital General de Reus, Tarragona, Spain

    Meritxell Arenas

  4. Gynecological Cancer Unit, Gynecology and Obstetrics Department, Hospital Clinic, Barcelona, Spain

    Jaume Pahisa

Authors
  1. Angeles Rovirosa
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  2. Izaskun Valduvieco
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  3. Carlos Ascaso
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  4. Antonio Herreros
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  5. Carlos Bautista
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  6. Ingrid Romera
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  7. Meritxell Arenas
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  8. Jaume Pahisa
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  9. Albert Biete
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Corresponding author

Correspondence to Angeles Rovirosa.

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Rovirosa, A., Valduvieco, I., Ascaso, C. et al. Daily schedule for high-dose-rate brachytherapy in postoperative treatment of endometrial carcinoma. Clin Transl Oncol 15, 111–116 (2013). https://doi.org/10.1007/s12094-012-0893-0

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  • DOI: https://doi.org/10.1007/s12094-012-0893-0

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