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Vaginal-cuff control and toxicity results of a daily HDR brachytherapy schedule in endometrial cancer patients

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Abstract

Purpose

To analyze the vaginal-cuff local control (VCC) and toxicity in postoperative endometrial carcinoma patients (EC) underwent high-dose-rate brachytherapy (HDR-BT) administered daily.

Materials and methods

154 consecutive patients received postoperative HDR-BT for EC from January 2007 to September 2011. FIGO-staging I–IIIC2 patients were divided into two groups according to risk classification: Group 1 (94/154) included high-risk or advanced disease patients and Group 2 (60/154) included intermediate-risk EC patients. Group 1 underwent external beam irradiation (EBI) plus HDR-BT (2 fractions of 5 Gy) and Group 2 underwent HDR-BT alone (4 fractions of 5 Gy). Toxicity evaluation was done with RTOG scores for bladder and rectum, and the objective criteria of LENT–SOMA for vagina.

Results

With a median follow-up of 46.7 months (36.6–61 months) only two patients developed vaginal-cuff recurrence in Group 1 (2.1 %) and none in group 2 (0 %). Early toxicity in Group 1 appeared 5.3 % in rectum, 7.5 % in bladder (G1–G2) and 2.1 % in vagina (G1); late toxicity was present in 7.3 % in rectum (all G1–G2 but 1 G3) and in 27.7 % in vagina (all G1–G2 but one G4). In Group 2, 6.7 % developed acute G1–G2 bladder and 6.6 % acute vaginal (G1–G2) toxicity. No late rectal or bladder toxicity was observed; 21.7 % of G1–G2 presented late problems in vagina.

Conclusions

The present HDR-BT schedule of 2 fractions of 5 Gy after EBI and 4 fractions of 5 Gy administered daily showed excellent results in terms of VCC and toxicity.

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Acknowledgments

Grant AECC Scientific Foundation. This work was presented, in part, at the 33th ESTROFORUM Meeting. Barcelona 2015.

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Authors and Affiliations

  1. Radiation Oncology Department, ICMHO, Functional Gynecologic Cancer Unit, Hospital Clinic Universitari, C/Villarroel no. 170, 08036, Barcelona, Spain

    I. Ríos, A. Rovirosa, I. Valduvieco, A. Herreros, L. Castilla, K. Holub & A. Biete

  2. Radiation Oncology Department, Cancer Institute, Centro Medico Imbanaco, Cali, Colombia

    I. Ríos

  3. Public and Health Department, Medicine Faculty, Universitat de Barcelona, Barcelona, Spain

    C. Ascaso

  4. Radiation Oncology Department, Hospital Sant Joan de Reus, Tarragona, Spain

    M. Arenas

  5. Radiation Oncology Department, Hospital General de Albacete, Albacete, Spain

    S. Sabater

  6. Gynecological Surgery, Functional Gynecologic Cancer Unit, Hospital Clinic I Universitari, Barcelona, Spain

    J. Pahisa

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  1. I. Ríos
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  2. A. Rovirosa
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  3. C. Ascaso
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  4. I. Valduvieco
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  6. L. Castilla
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  7. S. Sabater
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  8. K. Holub
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  9. J. Pahisa
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  11. M. Arenas
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Correspondence to I. Ríos.

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The authors declare that they have no conflict of interest.

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Informed consent was obtained from all individual participants included in the study.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Ríos, I., Rovirosa, A., Ascaso, C. et al. Vaginal-cuff control and toxicity results of a daily HDR brachytherapy schedule in endometrial cancer patients. Clin Transl Oncol 18, 925–930 (2016). https://doi.org/10.1007/s12094-015-1463-z

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  • DOI: https://doi.org/10.1007/s12094-015-1463-z

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