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Helicobacter pylori infection of the larynx may be an emerging risk factor for laryngeal squamous cell carcinoma

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Abstract

Introduction

Several studies have implicated Helicobacter pylori as a risk factor in laryngeal cancer, but other studies disagree. It is fundamental that the relationship between Helicobacter pylori and laryngeal cancer be verified in order to provide evidence of ways to prevent the initiation and development of this carcinoma.

Materials and methods

In total, 81 patients with laryngeal squamous cell carcinoma and 75 control subjects were enrolled in a case–control study. Semi-nested polymerase chain reaction techniques were applied to detect Helicobacter pylori in the laryngeal mucosa and enzyme-linked immunosorbent assays were used to detect serum antibodies against Helicobacter pylori. Risk factors associated with laryngeal carcinoma were analyzed using logistic regression models.

Results

The presence of Helicobacter pylori in the larynx was higher in patients with laryngeal cancer than in control subjects (71.6 vs. 25.3 %, p < 0.001). Among patients with laryngeal carcinoma, rates of Helicobacter pylori infection were higher in normal laryngeal tissues than in tumor tissues. After adjusting for confounding factors, regression analysis indicated that the microbe was an independent risk factor for laryngeal cancer (OR = 7.15, 95 % CI [3.29, 15.53], p < 0.001).

Conclusions

This study suggests that Helicobacter pylori is present in the mucosa of the larynx. The microorganism may be an independent risk factor for laryngeal squamous cell carcinoma. The laryngeal mucosa thus provides a reservoir for the bacteria possibly, and is a likely staging place for its transmission to other areas.

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Acknowledgments

The work was supported by National Natural Science Foundation of China. No. 81001203.

Conflict of interest

The authors disclose no conflicts.

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Authors and Affiliations

  1. Department of Otolaryngology, Eye, Ear, Nose, and Throat Hospital, Fudan University, Shanghai, China

    Hongli Gong, Liang Zhou, Lei Tao, Yong Shi & Lei Cheng

  2. Department of Clinical Laboratory, Eye, Ear, Nose, and Throat Hospital, Fudan University, Shanghai, China

    Yi Shi & Wenjun Cao

  3. Department of Clinical Laboratory, Nanhui Central Hospital, Shanghai, China

    Yi Shi

Authors
  1. Hongli Gong
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  2. Yi Shi
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  3. Liang Zhou
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  4. Lei Tao
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  5. Yong Shi
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  6. Wenjun Cao
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  7. Lei Cheng
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Corresponding author

Correspondence to Liang Zhou.

Additional information

H. Gong and Y. Shi are the joint first authors because of the equal contribution to this study.

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Gong, H., Shi, Y., Zhou, L. et al. Helicobacter pylori infection of the larynx may be an emerging risk factor for laryngeal squamous cell carcinoma. Clin Transl Oncol 14, 905–910 (2012). https://doi.org/10.1007/s12094-012-0879-y

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  • DOI: https://doi.org/10.1007/s12094-012-0879-y

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