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The association of annexin A2 and cancers

  • EDUCATIONAL SERIES—BLUE SERIES
  • Advances in Translational Oncology
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Abstract

Annexins are a group of calcium- and phospholipid-dependent proteins. As a member of the annexin, annexin A2 (Anxa2) is widely distributed in nucleus, cytoplasm and extracellular surface and mainly expressed in human endothelial cells, mononuclear cells, macrophages, marrow cells and some tumor cells. Accumulated evidences indicated that Anxa2 deregulation was associated with the occurrence, invasion and metastasis of cancers. Anxa2 up-regulation was related to the development, invasion, metastasis and drug resistance of hepatocellular carcinoma, colorectal cancer, breast cancer, pancreatic cancer, acute promyelocytic leukemia and renal cell carcinoma; while Anxa2 down-regulation was associated with prostate cancer, esophageal squamous carcinoma and nasopharyngeal carcinoma and sinonasal adenocarcinoma. The association between Anxa2 and malignant tumors as well as the potential action mechanisms were summarized in current work. Anxa2 might be used as a potential biomarker for the diagnosis, treatment and prognosis of certain tumors.

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Acknowledgments

This research was supported by grants from National Natural Science Foundation of China (81050010; 81171957) and Key Laboratory of Department of Education of Liaoning (LS2010050).

Conflict of interest

The authors declare that they have no conflict of interest relating to the publication of this manuscript.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, 116044, China

    Shuqing Liu

  2. Department of Clinical Medicine, Dalian Medical University, Dalian, 116044, China

    Xiaohui Zhang & Junwei Zong

  3. Department of Biotechnology, Dalian Medical University, Dalian, 116044, China

    Chunmei Guo & Ming-Zhong Sun

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  1. Xiaohui Zhang
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  2. Shuqing Liu
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  3. Chunmei Guo
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  4. Junwei Zong
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  5. Ming-Zhong Sun
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Corresponding authors

Correspondence to Shuqing Liu or Ming-Zhong Sun.

Additional information

S. Liu and X. Zhang contributed equally as the first authors.

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Zhang, X., Liu, S., Guo, C. et al. The association of annexin A2 and cancers. Clin Transl Oncol 14, 634–640 (2012). https://doi.org/10.1007/s12094-012-0855-6

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  • DOI: https://doi.org/10.1007/s12094-012-0855-6

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