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Gasdermin family: a promising therapeutic target for cancers and inflammation-driven diseases

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Journal of Cell Communication and Signaling Aims and scope

Abstract

This review focuses on current advances in researches of gasdermin family. The distinctive expression patterns and biological roles of members in this family were discussed. Most of them exhibit pore-forming activity on cell membranes and are executors for programmed cell death with cytokines release, and play roles in cancers and inflammation-driven diseases. Therefore, they can be used as potential therapeutic targets to treat related diseases.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China [NO. 81573733, NO. 81873130, NO. 81804025, NO. 81704056], Tianjin Municipal Natural Science Foundation [NO. 18JCYBJC94500], Scientific and Technological Research Program of Tianjin Municipal Education Commission [NO. 2017KJ164], Jiangxi Municipal Natural Science Foundation [NO. 20171ACB21075, NO. 20181BAB205073].

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  1. Danbin Wu and Yefei Chen contributed equally to this work.

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  1. School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, People’s Republic of China

    Danbin Wu, Yefei Chen, Yingxin Sun, Qing Gao, Bin Yu, Xijuan Jiang & Maojuan Guo

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  1. Danbin Wu
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  2. Yefei Chen
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Wu, D., Chen, Y., Sun, Y. et al. Gasdermin family: a promising therapeutic target for cancers and inflammation-driven diseases. J. Cell Commun. Signal. 14, 293–301 (2020). https://doi.org/10.1007/s12079-020-00564-5

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