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Correlation of Wnt and NOTCH pathways in esophageal squamous cell carcinoma

  • RESEARCH ARTICLE
  • Published:
Journal of Cell Communication and Signaling Aims and scope

Abstract

There is an inevitable association between cell signaling pathways and tumorigenesis. Wnt and notch pathways play important roles during development and self-renewal. Beside the independent role of such pathways on tumor progression, different cross talks between these pathways through tumorigenesis are emphasized. In this study, we analyzed cross talk between Wnt and NOTCH signaling pathways through assessment of probable correlation between MAML1 and PYGO2 as the main transcription factors of these pathways, respectively in esophageal squamous cell carcinoma (ESCC) patients. Levels of MAML1 and PYGO2 mRNA expression in 48 ESCC patients were compared to the correlated margin normal tissues using real-time polymerase chain reaction (PCR). Eleven out of 48 patients (22.9 %) have shown the concomitant MAML1/PYGO2 over expression in significant correlation with tumor size (p = 0.046) and depth of tumor invasion (p = 0.050). We showed that there is a significant correlation and feedback between these markers during the ESCC progression and metastasis.

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Acknowledgment

This work was supported by a grant from the Vice Chancellor for Research at Mashhad University of Medical Sciences, and was part of a Ph.D. student’s dissertation, No. 921202.

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Authors and Affiliations

  1. Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran

    Meysam Moghbeli & Mohammad Reza Abbaszadegan

  2. Medical Genetics Research Center, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran

    Mohammad Reza Abbaszadegan

  3. Department of Anesthesiology and Critical Care, Mashhad University of Medical Sciences, Mashhad, Iran

    Ebrahim Golmakani

  4. Addiction and Behavioral Sciences Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran

    Ebrahim Golmakani

  5. Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, 9613596135, Sabzevar, Iran

    Mohammad Mahdi Forghanifard

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  1. Meysam Moghbeli
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  2. Mohammad Reza Abbaszadegan
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  3. Ebrahim Golmakani
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  4. Mohammad Mahdi Forghanifard
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Correspondence to Mohammad Mahdi Forghanifard.

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Moghbeli, M., Abbaszadegan, M.R., Golmakani, E. et al. Correlation of Wnt and NOTCH pathways in esophageal squamous cell carcinoma. J. Cell Commun. Signal. 10, 129–135 (2016). https://doi.org/10.1007/s12079-016-0320-3

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  • DOI: https://doi.org/10.1007/s12079-016-0320-3

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