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Understanding Malignancies of the Thyroid Gland: Institutional Experience

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Abstract

To study the epidemiological, pathological characters and determine survival in patients diagnosed of having thyroid gland malignancies. Retrospective chart review of patients having thyroid gland malignancies, which were managed by the two senior authors at our tertiary care institute from January 2000 to December 2006, were performed and evaluated in terms of various clinical, operative and histological parameters. Patients in which follow up of at least 10 years are available were included in the study. Survival was enquired telephonically in those patients who got cured and did not consent to come for follow up. Slides were reviewed. Statistical analysis was done using SPSS statistical software. Kaplan–Meier method was used for calculating survival. A total of 182 patients were included in the study. Papillary carcinoma was the commonest malignant lesion with a frequency of 87.91% followed by follicular carcinoma (7.69%), medullary carcinoma (3.29%) and anaplastic carcinoma (1.09%). Female predominance was seen (F:M–5.06:1). The 5 year and 10 year survival rates were 89% and 73% respectively. The most common postoperative squeal was transient hypocalcaemia, seen in (27/182) 15% patients which was followed by permanent hypocalcaemia 16/182 (8.79%), transient recurrent laryngeal nerve paresis 12/182 (6.59%) and permanent recurrent laryngeal nerve palsy 8/182 (4.39%). Thyroid malignancies affect all age groups and have good long term prognosis. Management yields promising results and hence early and adequate treatment is emphasized.

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References

  1. Hayat MJ, Howlader N, Reichman ME, Edwards BK (2007) Cancer statistics, trends, and multiple primary cancer analyses from the surveillance, epidemiology, and end results (SEER) program. Oncologist 12(1):20–37

    Article  Google Scholar 

  2. Ron E, Lubin JH, Shore RE et al (1995) Thyroid cancer after exposure to external radiation: a pooled analysis of seven studies. Radiat Res 141(3):259–277

    Article  CAS  Google Scholar 

  3. Schneider AB, Bekerman C, Leland J et al (1997) Thyroid nodules in the follow-up of irradiated individuals: comparison of thyroid ultrasound with scanning and palpation. J Clin Endocrinol Metab 82(12):4020–4027

    CAS  PubMed  Google Scholar 

  4. Hundahl SA, Fleming ID, Fremgen AM, Menck HR (1998) A National Cancer Data Base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985–1995 [see comments]. Cancer 83(12):2638–2648

    Article  CAS  Google Scholar 

  5. Tunbridge WM, Evered DC, Hall R et al (1977) The spectrum of thyroid disease in a community: the Whickham survey. Clin Endocrinol (Oxf) 7(6):481–493

    Article  CAS  Google Scholar 

  6. Vander JB, Gaston EA, Dawber TR (1968) The significance of nontoxic thyroid nodules. Final report of a 15-year study of the incidence of thyroid malignancy. Ann Intern Med 69(3):537–540

    Article  CAS  Google Scholar 

  7. Hegedus L (2004) Clinical practice. The thyroid nodule. N Engl J Med 351(17):1764–1771

    Article  Google Scholar 

  8. Cooper DS, Doherty GM, Haugen BR et al (2006) Management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 16(2):109–142

    Article  Google Scholar 

  9. Mandel SJ (2004) A 64-year-old woman with a thyroid nodule. JAMA 292(21):2632–2642

    Article  CAS  Google Scholar 

  10. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ (2009) Cancer statistics, 2009. CA Cancer J Clin 59(4):225–249

    Article  Google Scholar 

  11. Ferlay J (2000) Cancer IAfRo. GLOBOCAN, Cancer incidence, mortality and prevalence worldwide. IARC Press, Lyon

    Google Scholar 

  12. Altekruse S, Das A, Cho H, Petkov V, Yu M (2015) Do US thyroid cancer incidence rates increase with socioeconomic status among people with health insurance? An observational study using SEER population-based data. BMJ Open 5(12):e009843

    Article  Google Scholar 

  13. Sherman SI (2003) Thyroid carcinoma. Lancet 361(9356):501–511

    Article  Google Scholar 

  14. Mazzaferri EL, Jhiang SM (1994) Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer. Am J Med 97(5):418–428

    Article  CAS  Google Scholar 

  15. Jonklaas J, Nogueras-Gonzalez G, Munsell M et al (2012) The impact of age and gender on papillary thyroid cancer survival. J Clin Endocrinol Metab 97(6):E878–E887

    Article  CAS  Google Scholar 

  16. Ushenkova LN, Koterov AN, Biryukov AP (2015) Pooled analysis of RET/PTC gene rearrangement rate in sporadic and radiogenic thyroid papillary carcinoma. Radiat Biol Radioecol 55(4):355–388

    CAS  Google Scholar 

  17. Sozzi G, Bongarzone I, Miozzo M et al (1992) Cytogenetic and molecular genetic characterization of papillary thyroid carcinomas. Genes Chromosomes Cancer 5(3):212–218

    Article  CAS  Google Scholar 

  18. Tarashchenko YN, Kovalenko AE, Bolgov MY et al (2015) Braf-status of papillary thyroid carcinomas and strategy of surgical treatment. Klin Khir 6:49–54

    Google Scholar 

  19. Jiang L, Chu H, Zheng H (2016) B-Raf mutation and papillary thyroid carcinoma patients. Oncol Lett 11(4):2699–2705

    Article  CAS  Google Scholar 

  20. Kitamura Y, Shimizu K, Tanaka S, Emi M (1999) Genetic alterations in thyroid carcinomas. Nihon Ika Daigaku Zasshi. 66(5):319–323

    Article  CAS  Google Scholar 

  21. Song YS, Lim JA, Park YJ (2015) Mutation profile of well-differentiated thyroid cancer in Asians. Endocrinol Metab (Seoul) 30(3):252–262

    Article  CAS  Google Scholar 

  22. Sobrinho-Simoes M, Preto A, Rocha AS et al (2005) Molecular pathology of well-differentiated thyroid carcinomas. Virchows Arch 447(5):787–793

    Article  CAS  Google Scholar 

  23. Grubbs EG, Rich TA, Li G et al (2008) Recent advances in thyroid cancer. Curr Probl Surg 45(3):156–250

    Article  Google Scholar 

  24. Majumder KR, Karmakar R, Karim SS, Al-Mamun A (2016) Malignancy in solitary thyroid nodule. Mymensingh Med J 25(1):39–44

    CAS  PubMed  Google Scholar 

  25. Frates MC, Benson CB, Charboneau JW et al (2005) Management of thyroid nodules detected at US: Society of radiologists in ultrasound consensus conference statement. Radiology 237(3):794–800

    Article  Google Scholar 

  26. Brander AE, Viikinkoski VP, Nickels JI, Kivisaari LM (2000) Importance of thyroid abnormalities detected at US screening: a 5-year follow-up. Radiology 215(3):801–806

    Article  CAS  Google Scholar 

  27. Baloch ZW, Cibas ES, Clark DP et al (2008) The National Cancer Institute Thyroid fine needle aspiration state of the science conference: a summation. Cytojournal 5:6

    Article  Google Scholar 

  28. Cibas ES, Ali SZ (2009) The bethesda system for reporting thyroid cytopathology. Am J Clin Pathol 132(5):658–665

    Article  Google Scholar 

  29. Bestepe N, Ozdemir D, Tam AA et al (2016) Malignancy risk and false-negative rate of fine needle aspiration cytology in thyroid nodules ≥ 4.0 cm. Surgery 160:405–412

    Article  Google Scholar 

  30. Cao H, Kao RH, Hsieh MC (2016) Comparison of core-needle biopsy and fine-needle aspiration in screening for thyroid malignancy: a systematic review and meta-analysis. Curr Med Res Opin 32:1291–1301

    Article  Google Scholar 

  31. Yeh MW, Demircan O, Ituarte P, Clark OH (2004) False-negative fine-needle aspiration cytology results delay treatment and adversely affect outcome in patients with thyroid carcinoma. Thyroid 14(3):207–215

    Article  Google Scholar 

  32. Barabadze E, Burkadze G, Munjishvili V (2016) Accurate diagnosis of thyroid nodules: a review of diagnostic dilemmas on thyroid fine-needle aspiration biopsies. Georgian Med News 252:89–95

    Google Scholar 

  33. Layfield LJ, Cibas ES, Gharib H, Mandel SJ (2009) Thyroid aspiration cytology: current status. CA Cancer J Clin 59(2):99–110

    Article  Google Scholar 

  34. Al-Qurayshi Z, Hauch A, Srivastav S, Aslam R, Friedlander P, Kandil E (2016) A national perspective of the risk, presentation, and outcomes of pediatric thyroid cancer. JAMA Otolaryngol Head Neck Surg 142:472–478

    Article  Google Scholar 

  35. Eichhorn W, Tabler H, Lippold R, Lochmann M, Schreckenberger M, Bartenstein P (2003) Prognostic factors determining long-term survival in well-differentiated thyroid cancer: an analysis of four hundred eighty-four patients undergoing therapy and aftercare at the same institution. Thyroid 13(10):949–958

    Article  Google Scholar 

  36. Veronese N, Luchini C, Nottegar A et al (2015) Prognostic impact of extra-nodal extension in thyroid cancer: a meta-analysis. J Surg Oncol 112(8):828–833

    Article  Google Scholar 

  37. Mazzaferri EL (1993) Management of a solitary thyroid nodule. N Engl J Med 328(8):553–559

    Article  CAS  Google Scholar 

  38. Pingpank JF Jr, Sasson AR, Hanlon AL, Friedman CD, Ridge JA (2002) Tumor above the spinal accessory nerve in papillary thyroid cancer that involves lateral neck nodes: a common occurrence. Arch Otolaryngol Head Neck Surg 128(11):1275–1278

    Article  Google Scholar 

  39. Ruegemer JJ, Hay ID, Bergstralh EJ, Ryan JJ, Offord KP, Gorman CA (1988) Distant metastases in differentiated thyroid carcinoma: a multivariate analysis of prognostic variables. J Clin Endocrinol Metab 67(3):501–508

    Article  CAS  Google Scholar 

  40. Sisson JC, Giordano TJ, Jamadar DA et al (1996) 131-I treatment of micronodular pulmonary metastases from papillary thyroid carcinoma. Cancer 78(10):2184–2192

    Article  CAS  Google Scholar 

  41. Haigh PI, Urbach DR, Rotstein LE (2005) Extent of thyroidectomy is not a major determinant of survival in low- or high-risk papillary thyroid cancer. Ann Surg Oncol 12(1):81–89

    Article  Google Scholar 

  42. Haigh PI, Urbach DR, Rotstein LE (2004) AMES prognostic index and extent of thyroidectomy for well-differentiated thyroid cancer in the United States. Surgery. 136(3):609–616

    Article  Google Scholar 

  43. Jonklaas J, Sarlis NJ, Litofsky D et al (2006) Outcomes of patients with differentiated thyroid carcinoma following initial therapy. Thyroid 16(12):1229–1242

    Article  Google Scholar 

  44. Bilimoria KY, Bentrem DJ, Ko CY et al (2007) Extent of surgery affects survival for papillary thyroid cancer. Ann Surg 246(3):375–381 (discussion 381–374)

    Article  Google Scholar 

  45. McDougall IR, Hay ID (2007) ATA guidelines: do patients with stage I thyroid cancer benefit from (131)I? Thyroid 17(6):595–596 (author reply 596–597)

    Article  Google Scholar 

  46. Eustatia-Rutten CF, Romijn JA, Guijt MJ et al (2003) Outcome of palliative embolization of bone metastases in differentiated thyroid carcinoma. J Clin Endocrinol Metab 88(7):3184–3189

    Article  CAS  Google Scholar 

  47. Muresan MM, Olivier P, Leclere J et al (2008) Bone metastases from differentiated thyroid carcinoma. Endocr Relat Cancer 15(1):37–49

    Article  CAS  Google Scholar 

  48. Thompson LD, Wieneke JA, Paal E, Frommelt RA, Adair CF, Heffess CS (2001) A clinicopathologic study of minimally invasive follicular carcinoma of the thyroid gland with a review of the English literature. Cancer 91(3):505–524

    Article  CAS  Google Scholar 

  49. Lopez-Penabad L, Chiu AC, Hoff AO et al (2003) Prognostic factors in patients with Hurthle cell neoplasms of the thyroid. Cancer 97(5):1186–1194

    Article  Google Scholar 

  50. Herrera MF, Hay ID, Wu PS et al (1992) Hurthle cell (oxyphilic) papillary thyroid carcinoma: a variant with more aggressive biologic behavior. World J Surg. 16(4):669–674 (discussion 774–665)

    Article  CAS  Google Scholar 

  51. Block MA (1990) Surgical treatment of medullary carcinoma of the thyroid. Otolaryngol Clin N Am 23(3):453–473

    CAS  Google Scholar 

  52. Are C, Shaha AR (2006) Anaplastic thyroid carcinoma: biology, pathogenesis, prognostic factors, and treatment approaches. Ann Surg Oncol 13(4):453–464

    Article  Google Scholar 

  53. Kebebew E, Greenspan FS, Clark OH, Woeber KA, McMillan A (2005) Anaplastic thyroid carcinoma. Treatment outcome and prognostic factors. Cancer 103(7):1330–1335

    Article  Google Scholar 

  54. Untch BR, Olson JA Jr (2006) Anaplastic thyroid carcinoma, thyroid lymphoma, and metastasis to thyroid. Surg Oncol Clin N Am 15(3):661–679

    Article  Google Scholar 

  55. Venkatesh YS, Ordonez NG, Schultz PN, Hickey RC, Goepfert H, Samaan NA (1990) Anaplastic carcinoma of the thyroid. A clinicopathologic study of 121 cases. Cancer 66(2):321–330

    Article  CAS  Google Scholar 

  56. Kwon J, Kim BH, Jung HW, Besic N, Sugitani I, Wu HG (2016) The prognostic impacts of postoperative radiotherapy in the patients with resected anaplastic thyroid carcinoma: a systematic review and meta-analysis. Eur J Cancer 59:34–45

    Article  Google Scholar 

  57. Lennon P, Deady S, Healy ML et al (2016) Anaplastic thyroid carcinoma: Failure of conventional therapy but hope of targeted therapy. Head Neck 38(Suppl 1):E1122–E1129

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Otolaryngology and Head Neck Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India

    Jaimanti Bakshi, Sourabha Kumar Patro, Navjot Kaur, Naresh Kumar Panda & Grace Budhiraja

  2. Department of Otolaryngology and Head Neck Surgery, All India Institute of Medical Sciences, AIIMS, BASNI, Jodhpur, 342005, India

    Sourabha Kumar Patro

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  1. Jaimanti Bakshi
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Correspondence to Sourabha Kumar Patro.

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Bakshi, J., Patro, S.K., Kaur, N. et al. Understanding Malignancies of the Thyroid Gland: Institutional Experience. Indian J Otolaryngol Head Neck Surg 70, 482–489 (2018). https://doi.org/10.1007/s12070-018-1492-3

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  • DOI: https://doi.org/10.1007/s12070-018-1492-3

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