Abstract
Outer membrane vesicles are nano-sized spheres produced predominantly by gram-negative bacteria. They play a significant role in cell-to-cell communication, virulence, nutrition and protection of the bacterial cells from various stress factors. Recent evidences also underscore their involvement in antibiotic-resistance of bacteria. In this article, we discuss the physiological importance of these vesicles with potential use in the development of vaccines and drug delivery.
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S N Chatterjee and K Chaudhuri, Outer Membrane Vesicles of Bacteria, Springer, 2013.
M K Chattopadhyay and M V Jagannadham, Vesicle-mediated resistance to antibiotics in bacteria, Front. Microbiol., Vol.6, p.758, 2015. doi: 10.3389/fmicb.2015.00758
C Chiranjit and M V Jagannadham, Virulence factors are released in association with outer membrane vesicles of Pseudomonas syringae pv. tomato T1 during normal growth, Biochim. Biophys. Acta, 1834:231–239, 2013.
B L Deatherage and B T Cookson, Membrane vesicle release in bacteria, eukaryotes, and achaea: a conserved yet underappreciated aspect of microbial Life, Infect. Immun., Vol.80, pp.1948–1957, 2012.
J L Kadurugamuwa and T J Beveridge, Delivery of the non-membranepermeative antibiotic gentamicin into mammalian cells by using Shigella flexneri membrane vesicles, Antimicrob. Agents. Chemother., Vol.42, pp.1476–1483, 1998.
M J Kuehn and Kesty N C, Bacterial outer membrane vesicles and the host-pathogen interaction, Genes Dev., Vol.19, pp.2645–2655, 2005.
H M Kulkarni and M V Jagannadham, Biogenesis and multifaceted role of outer membrane vesicles from gram-negative bacteria, Microbiology, Vol.160, pp.2109–2121, 2014.
E Y Lee, D S Choi, K P Kim and Y S Gho, Proteomics in gram-negative bacterial outer membrane vesicles, Mass. Spectrom. Rev., Vol.27, pp.535–555, 2008.
I A Macdonald and M J Kuehn, Stress-induced outer membrane vesicle production by Pseudomonas aeruginosa, J Bacteriol., Vol.195, pp.2971–2981, 2013.
A J Manning and M J Kuehn, Contribution of bacterial outer membrane vesicles to innate bacterial defense, BMC. Microbiol., Vol.11, p.258, 2011.
E S Medvedeva, N B Baranova, A A Mouzykantov, T Y Grigorieva, M N Davydova, M V Trushin, O A Chernova and V M Chernov, Adaptation of mycoplasmas to antimicrobial agents: Acholeplasma laidlawii extracellular vesicles mediate the export of ciprofloxacin and a mutant gene related to the antibiotic target, Scientific World Journal, Vol.29, p.150615, 2014.
S Roier, J C Fenninger, D R Leitner, G N Rechberger, J Reidl and S Schild, Immunogenicity of Pasteurella multocida and Mannheimia haemolytica outer membrane vesicles, Int. J. Med. Microbiol., Vol.303, pp.247–256, 2013.
N Roy, S Barman, A Ghosh, A Pal, K Chakraboty, S S Das, D R Saha, S Yamasaki and H Koley, Immunogenicity and protective efficacy of Vibrio cholerae outer membrane vesicles in rabbit model, FEMS Immun. Med. Microbiol., Vol.60, pp.18–27, 2010.
C Rumbo, E Fernández-Moreira, M Merino, M Poza, J A Mendez, N C Soares, A Mosquera, F Chaves and G Bou, Horizontal transfer of the OXA-24 carbapenemase gene via outer membrane vesicles: a newmechanism of dissemination of carbapenem resistance genes in Acinetobacter baumannii, Antimicrob. Agents Chemother., Vol.55, pp.3084–3090, 2011.
S Sengupta and M K Chattopadhyay, Antibiotic resistance in bacteria: A global challenge, Resonance, Vol.17, No.2, pp.177–191, 2012.
Y Tashiro, M Toyofuku, T Nakajima-Kambe, H Uchiyama and N Nomura, Bicyclic compounds repress membrane vesicle production and Pseudomonas quinolone signal synthesis in Pseudomonas aeruginosa, FEMS MicrobiolLett, Vol.304, pp.123–130, 2010.
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M V Jagannadham and M K Chattopadhyay are working at the Centre for Cellular and Molecular Biology (CSIR), Hyderabad on structural and functional aspects of bacterial vesicles.
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Jagannadham, M.V., Chattopadhyay, M.K. Role of outer membrane vesicles of bacteria. Reson 20, 711–725 (2015). https://doi.org/10.1007/s12045-015-0228-x
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DOI: https://doi.org/10.1007/s12045-015-0228-x