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Aldosterone synthase C-344T, angiotensin II type 1 receptor A1166C and 11-β hydroxysteroid dehydrogenase G534A gene polymorphisms and essential hypertension in the population of Odisha, India

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An Erratum to this article was published on 20 June 2015

Abstract

Essential hypertension which accounts 90–95% of the total hypertension cases is affected by both genetic and environmental factors. This study was undertaken to investigate the association of aldosterone synthase C-344T, angiotensin II type I receptor A1166C and 11- β hydroxysteroid dehydrogenase type 2 G534A polymorphisms with essential hypertension in the population of Odisha, India. A total of 246 hypertensive subjects (males, 159; females, 87) and 274 normal healthy individuals (males, 158; females, 116) were enrolled in this study based on the inclusion and exclusion criteria. Analysis of genetic and biochemical data revealed that in this population the CT and TT genotypes of aldosterone synthase C-344T polymorphism, frequency of alcohol consumption and aldosterone levels were significantly high among the total as well as male hypertensives, while the AC and CC genotypes of angiotensin II type I receptor A1166C polymorphism were significantly high among the total as well as female hypertensives. High density lipoprotein levels were higher in male hypertensives.

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Acknowledgements

We acknowledge the Council of Scientific and Industrial Research, New Delhi, for providing fellowship to Manisha Patnaik to carry out the research (sanction number: 09/547(0004)2009-EMR-I). We also acknowledge the School of Biotechnology, Kalinga Institute of Industrial Technology, Bhubaneswar for registering Mrs Manisha Patnaik as a Ph.D. student (registration number: 11396621439), Dr S. K. Kar, Director of Regional Medical Research Centre, Bhubaneswar, for providing necessary laboratory facilities for the study, the Regional Medical Research Centre, Indian Council of Medical Research, Bhubaneswar, for additional intramural financial help, and the patients who participated in the study.

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Authors and Affiliations

  1. Department of Molecular Biology, Regional Medical Research Centre, Chandrasekharpur, Bhubaneswar, 751 023, India

    MANISHA PATNAIK, PALLABI PATI & MANORANJAN RANJIT

  2. Department of Medicine, Capital Hospital, Bhubaneswar, 751 001, India

    SURENDRA N. SWAIN

  3. Department of Medicine, VSS Medical College, Burla, 768 017, India

    MANOJ K. MOHAPATRA

  4. Clinical Division, Regional Medical Research Centre, Chandrasekharpur, Bhubaneswar, 751 023, India

    BHAGIRATHI DWIBEDI & SHANTANU K. KAR

  5. School of Biotechnology, Kalinga Institute of Industrial Technology, Bhubaneswar, 751 024, India

    MANISHA PATNAIK

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  1. MANISHA PATNAIK
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Correspondence to BHAGIRATHI DWIBEDI or MANORANJAN RANJIT.

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[Patnaik M., Pati P., Swain S. N., Mohapatra M. K., Dwibedi B., Kar S. K. and Ranjit M. 2014 Aldosterone synthase C-344T, angiotensin II type 1 receptor A1166C and 11-β hydroxysteroid dehydrogenase G534A gene polymorphisms and essential hypertension in the population of Odisha, India. J. Genet. 93, xx–xx]

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PATNAIK, M., PATI, P., SWAIN, S.N. et al. Aldosterone synthase C-344T, angiotensin II type 1 receptor A1166C and 11-β hydroxysteroid dehydrogenase G534A gene polymorphisms and essential hypertension in the population of Odisha, India. J Genet 93, 799–808 (2014). https://doi.org/10.1007/s12041-014-0464-y

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